STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tagg_0733Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR004843:IPR000979; KEGG: dal:Dalk_3260 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: B8D4Y4 Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. (171 aa)    
Predicted Functional Partners:
Tagg_0732
Heat shock protein Hsp20; COGs: COG0071 Molecular chaperone (small heat shock protein); InterPro IPR017447:IPR002068:IPR007052; KEGG: gur:Gura_2833 heat shock protein HSP20; PFAM: heat shock protein Hsp20; CS; SPTR: B8D4Y5 Small heat shock protein Hsp20; PFAM: Hsp20/alpha crystallin family; Belongs to the small heat shock protein (HSP20) family.
       0.811
Tagg_0735
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002139:IPR011611; KEGG: hiq:CGSHiGG_05785 ribokinase; PFAM: PfkB domain protein; SPTR: A3DLR5 PfkB domain protein; PFAM: pfkB family carbohydrate kinase.
  
  
 0.752
Tagg_0734
COGs: COG2820 Uridine phosphorylase; InterPro IPR000845:IPR010058; KEGG: ara:Arad_9873 uridine phosphorylase; PFAM: purine or other phosphorylase family 1; SPTR: B8D4Y3 Uridine phosphorylase; TIGRFAM: uridine phosphorylase; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD); uridine phosphorylase.
       0.742
Tagg_1368
dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.721
Tagg_0736
Hypothetical protein.
       0.671
Tagg_0558
1-Cys peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 
 0.630
Tagg_0731
Protein of unknown function UPF0047; COGs: COG0432 conserved hypothetical protein; InterPro IPR001602; KEGG: afw:Anae109_2751 hypothetical protein; PFAM: protein of unknown function UPF0047; SPTR: A3DLQ9 Putative uncharacterized protein; PFAM: Uncharacterised protein family UPF0047; TIGRFAM: conserved hypothetical protein TIGR00149.
       0.594
Tagg_0730
COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR002638; KEGG: nis:NIS_1072 nicotinate phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase; SPTR: B8D4Y7 Quinolinate phosphoribosyl transferase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: putative nicotinate phosphoribosyltransferase.
       0.591
Tagg_0737
Hypothetical protein; SPTR: B8D4Y0 Putative uncharacterized protein.
       0.526
Tagg_1067
COGs: COG0180 Tryptophanyl-tRNA synthetase; InterPro IPR002306:IPR002305:IPR001412; KEGG: tryptophanyl-tRNA synthetase; K01867 tryptophanyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ib; PRIAM: Tryptophan--tRNA ligase; SPTR: B8D6Q2 Tryptophanyl-tRNA synthetase; TIGRFAM: tryptophanyl-tRNA synthetase; PFAM: tRNA synthetases class I (W and Y); TIGRFAM: tryptophanyl-tRNA synthetase.
 
   
 0.403
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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