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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (330 aa)    
Predicted Functional Partners:
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
  
 
 0.986
Tagg_0807
Hypothetical protein; SPTR: B8D4S5 DUF83 domain containing protein; PFAM: Domain of unknown function DUF83.
   
 
 0.969
Tagg_0810
CRISPR-associated protein, Csa1 family; COGs: COG4343 conserved hypothetical protein; InterPro IPR009260; PFAM: Protein of unknown function DUF911 endonuclease-like; SPTR: B8D4S8 CRISPR-associated protein, Csa1 family; TIGRFAM: CRISPR-associated protein, Csa1 family; PFAM: Archaeal protein of unknown function (DUF911); TIGRFAM: CRISPR-associated protein, Csa1 family.
 
   
 0.943
Tagg_0800
CRISPR-associated helicase Cas3; COGs: COG1203 helicase; InterPro IPR001650:IPR000408:IPR006474; KEGG: amc:MADE_00865 CRISPR-associated helicase Cas3; PFAM: helicase domain protein; SMART: helicase domain protein; SPTR: B8D4R9 CRISPR-associated ATP-dependent RNA helicase-like protein; TIGRFAM: CRISPR-associated helicase Cas3; PFAM: DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3.
 
  
 0.838
Tagg_0099
CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
   
 
 0.775
Tagg_0803
CRISPR-associated autoregulator, DevR family; COGs: COG1857 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR002764:IPR010154; PFAM: CRISPR-associated regulatory Csa2 family protein; SPTR: B8D4S2 CRISPR-associated autoregulator, DevR family; TIGRFAM: CRISPR-associated regulatory protein, Csa2 family; CRISPR-associated autoregulator DevR family; PFAM: CRISPR-associated negative autoregulator DevR/Csa2; TIGRFAM: CRISPR-associated autoregulator DevR family; CRISPR-associated regulatory protein, Csa2 family.
 
   
 0.584
Tagg_0802
InterPro IPR010153; PFAM: CRISPR-associated protein, MJ0382; SPTR: B8D4S1 CRISPR-associated protein Cas5; PFAM: CRISPR-associated protein (Cas_Cas5).
     
 0.455
Tagg_0886
N-6 DNA methylase; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR002296:IPR007409:IPR003356:IPR002052; KEGG: fta:FTA_1029 putative N-6 DNA methylase; PFAM: N-6 DNA methylase; protein of unknown function DUF450; SPTR: B9LX36 N-6 DNA methylase; PFAM: N-6 DNA Methylase.
 
   0.429
Tagg_0769
COGs: COG1483 ATPase (AAA+ superfamily); KEGG: sat:SYN_01847 AAA family ATPase; SPTR: Q9YF25 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF499).
  
   
 0.420
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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