STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
Tagg_0391
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: dal:Dalk_1629 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: B8D430 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; PFAM: domain; Transketolase, C-terminal domain.
  
 
 0.937
Tagg_0392
2-oxoglutarate ferredoxin oxidoreductase, beta subunit; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: sfu:Sfum_0016 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: B8D429 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
  
 
 0.933
Tagg_1265
COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766:IPR011896; KEGG: dat:HRM2_41100 PorB3; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: A2BLG9 2-oxoglutarate synthase subunit korB; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family.
  
 
 0.933
Tagg_1264
2-oxoglutarate synthase; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: dvm:DvMF_0184 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PRIAM: 2-oxoglutarate synthase; SPTR: Q9YA13 2-oxoacid:ferredoxin oxidoreductase alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase.
  
 
 0.932
Tagg_0393
COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR018202; KEGG: afw:Anae109_1896 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: B8D428 2-oxoglutarate oxidoreductase gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase.
  
 
 0.931
Tagg_0390
2-oxoglutarate ferredoxin oxidoreductase, delta subunit; InterPro IPR001450:IPR017900; KEGG: dal:Dalk_1630 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: B8D431 2-oxoglutarate ferredoxin oxidoreductase, delta subunit.
    
 0.930
Tagg_1026
NADH dehydrogenase (ubiquinone) 30 kDa subunit; COGs: COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductase; InterPro IPR001268:IPR006137; KEGG: ndhK; NADH dehydrogenase 27 kDa subunit; K05582 NADH dehydrogenase I subunit K; PFAM: NADH dehydrogenase (ubiquinone) 30 kDa subunit; NADH ubiquinone oxidoreductase 20 kDa subunit; SPTR: B8D5A0 NADH-quinone oxidoreductase, B subunit; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; Respiratory-chain NADH dehydrogenase, 30 Kd subunit.
  
 
 0.927
Tagg_0421
Thiolase; COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR020441:IPR002155; KEGG: gur:Gura_4354 thiolase; PFAM: Thiolase; SPTR: B8D4F6 Thiolase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain.
  
 0.915
Tagg_0340
acetyl-CoA synthetase (ADP-forming) beta subunit; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR011761; KEGG: dal:Dalk_1024 acetyl coenzyme A synthetase (ADP forming), alpha domain protein; SPTR: A3DNX4 Branched-chain acyl-CoA synthetase (ADP-forming) beta subunit / acetyl-CoA synthetase (ADP-forming) beta subunit.
    
 0.889
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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