Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tagg_1069COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: hypothetical protein LOC100248560; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: A3DLU1 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family. (241 aa)    
Predicted Functional Partners:
Tagg_0444
Rhomboid family protein; COGs: COG0705 membrane protein; InterPro IPR002610; KEGG: dvu:DVU1023 rhomboid family protein; PFAM: Rhomboid family protein; SPTR: B8D2L0 Rhomboid family protein; PFAM: Rhomboid family.
  
  
 0.704
Tagg_1070
Polyprenyl synthetase; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: mxa:MXAN_0894 putative farnesyltranstransferase; PFAM: Polyprenyl synthetase; SPTR: B8D6Q0 Polyprenyl synthetase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
  
    0.684
Tagg_1279
Transcriptional regulator, XRE family; COGs: COG1813 transcription factor homolog of eukaryotic MBF1; InterPro IPR001387; KEGG: similar to ethylene-responsive transcription coactivator; K03627 putative transcription factor; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; SPTR: B8D664 Predicted transcription factor; PFAM: Helix-turn-helix; TIGRFAM: conserved hypothetical protein TIGR00270.
  
 
 0.578
Tagg_1068
Orotidine 5'-phosphate decarboxylase; COGs: COG0269 3-hexulose-6-phosphate synthase and related protein; InterPro IPR001754; KEGG: kpn:KPN_02957 putative hexulose 6 phosphate synthase; PFAM: Orotidine 5'-phosphate decarboxylase; SPTR: B8D6Q1 Hexulose-6-phosphate synthase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: 3-hexulose-6-phosphate synthase.
       0.569
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.503
moaC
GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
     
 0.489
Tagg_0780
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR006220:IPR011702:IPR001317:IPR001674:IPR 000991:IPR004739; KEGG: mes:Meso_0495 GMP synthase; PFAM: glutamine amidotransferase class-I; GMP synthase domain protein; PRIAM: GMP synthase (glutamine-hydrolyzing); SPTR: B8D3X4 GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
       0.458
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
  
 0.402
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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