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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tagg_1069COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: hypothetical protein LOC100248560; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: A3DLU1 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family. (241 aa)    
Predicted Functional Partners:
Tagg_1070
Polyprenyl synthetase; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: mxa:MXAN_0894 putative farnesyltranstransferase; PFAM: Polyprenyl synthetase; SPTR: B8D6Q0 Polyprenyl synthetase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
  
    0.687
Tagg_0444
Rhomboid family protein; COGs: COG0705 membrane protein; InterPro IPR002610; KEGG: dvu:DVU1023 rhomboid family protein; PFAM: Rhomboid family protein; SPTR: B8D2L0 Rhomboid family protein; PFAM: Rhomboid family.
  
    0.677
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.605
Tagg_1068
Orotidine 5'-phosphate decarboxylase; COGs: COG0269 3-hexulose-6-phosphate synthase and related protein; InterPro IPR001754; KEGG: kpn:KPN_02957 putative hexulose 6 phosphate synthase; PFAM: Orotidine 5'-phosphate decarboxylase; SPTR: B8D6Q1 Hexulose-6-phosphate synthase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: 3-hexulose-6-phosphate synthase.
       0.571
moaC
GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
     
 0.534
Tagg_0780
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR006220:IPR011702:IPR001317:IPR001674:IPR 000991:IPR004739; KEGG: mes:Meso_0495 GMP synthase; PFAM: glutamine amidotransferase class-I; GMP synthase domain protein; PRIAM: GMP synthase (glutamine-hydrolyzing); SPTR: B8D3X4 GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
       0.457
Tagg_0407
Aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR013977:IPR006222:IPR006223; KEGG: pub:SAR11_0666 glycine cleavage system protein T2; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; SPTR: B8D2P4 Aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein.
     
 0.441
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
  
 0.437
Tagg_0963
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR003148:IPR006037; KEGG: vsa:VSAL_I0072 potassium transporter peripheral membrane component; PFAM: TrkA-N domain protein; SPTR: A3DNI5 TrkA-N domain protein; PFAM: TrkA-N domain; TrkA-C domain.
  
 
 0.435
Tagg_0596
Dihydropteroate synthase-related protein; COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489:IPR005236; KEGG: mfa:Mfla_1581 dihydropteroate synthase, DhpS; PFAM: dihydropteroate synthase DHPS; SPTR: B8D3R8 Dihydropteroate synthase-related protein; TIGRFAM: dihydropteroate synthase-related protein; TIGRFAM: dihydropteroate synthase-related protein.
     
 0.426
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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