node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EXD2 | FANCM | E5SE79 | A0A0V1AXH6 | Exonuclease 3'-5' domain-containing protein 2. | Fanconi anemia group M protein. | 0.665 |
EXD2 | RPA1 | E5SE79 | A0A0V1AUK0 | Exonuclease 3'-5' domain-containing protein 2. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.824 |
EXD2 | Rpa2 | E5SE79 | A0A0V1BI36 | Exonuclease 3'-5' domain-containing protein 2. | Replication protein A 32 kDa subunit. | 0.582 |
EXD2 | T01_11322 | E5SE79 | A0A0V1B774 | Exonuclease 3'-5' domain-containing protein 2. | Uncharacterized protein. | 0.889 |
EXD2 | TOP3A | E5SE79 | E5SGH1 | Exonuclease 3'-5' domain-containing protein 2. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.740 |
EXD2 | rmi1 | E5SE79 | A0A0V1B452 | Exonuclease 3'-5' domain-containing protein 2. | RecQ-mediated genome instability protein 1. | 0.534 |
EXD2 | sas6 | E5SE79 | A0A0V1C3T5 | Exonuclease 3'-5' domain-containing protein 2. | Spindle assembly abnormal protein 6-like protein. | 0.575 |
FANCM | EXD2 | A0A0V1AXH6 | E5SE79 | Fanconi anemia group M protein. | Exonuclease 3'-5' domain-containing protein 2. | 0.665 |
FANCM | RFWD3 | A0A0V1AXH6 | A0A0V1B167 | Fanconi anemia group M protein. | E3 ubiquitin-protein ligase RFWD3. | 0.522 |
FANCM | RPA1 | A0A0V1AXH6 | A0A0V1AUK0 | Fanconi anemia group M protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.997 |
FANCM | Rpa2 | A0A0V1AXH6 | A0A0V1BI36 | Fanconi anemia group M protein. | Replication protein A 32 kDa subunit. | 0.993 |
FANCM | T01_11322 | A0A0V1AXH6 | A0A0V1B774 | Fanconi anemia group M protein. | Uncharacterized protein. | 0.923 |
FANCM | TIPIN | A0A0V1AXH6 | A0A0V1BF81 | Fanconi anemia group M protein. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.416 |
FANCM | TOP3A | A0A0V1AXH6 | E5SGH1 | Fanconi anemia group M protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.981 |
FANCM | rmi1 | A0A0V1AXH6 | A0A0V1B452 | Fanconi anemia group M protein. | RecQ-mediated genome instability protein 1. | 0.981 |
FANCM | sas6 | A0A0V1AXH6 | A0A0V1C3T5 | Fanconi anemia group M protein. | Spindle assembly abnormal protein 6-like protein. | 0.994 |
Gins4 | RPA1 | A0A0V1B861 | A0A0V1AUK0 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.919 |
Gins4 | Rpa2 | A0A0V1B861 | A0A0V1BI36 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | Replication protein A 32 kDa subunit. | 0.745 |
Gins4 | T01_11322 | A0A0V1B861 | A0A0V1B774 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | Uncharacterized protein. | 0.890 |
Gins4 | TIPIN | A0A0V1B861 | A0A0V1BF81 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.954 |