STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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T01_5372Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] (448 aa)    
Predicted Functional Partners:
NFS1
Cysteine desulfurase, mitochondrial.
   
 0.987
Mocs2-2
Molybdopterin synthase catalytic subunit 2.
 
 0.907
Lin7b
Protein lin-7-like protein B.
   
 
 0.876
sseA
3-mercaptopyruvate sulfurtransferase.
   
 0.795
cin
Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
 
 0.788
MOCOS
Molybdenum cofactor sulfurase.
  
 
 0.782
Mocs1
Molybdenum cofactor biosynthesis protein 1.
  
 
 0.773
T01_10759
Uncharacterized protein.
   
 0.765
ATG12
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.
    
 0.736
atg3
Autophagy-related protein 3.
   
 0.727
Your Current Organism:
Trichinella spiralis
NCBI taxonomy Id: 6334
Other names: T. spiralis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.