node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDH10851.1 | egtA | SAMN05421869_101487 | SAMN05421869_101483 | Pyridoxal 5-phosphate dependent beta-lyase. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | 0.460 |
SDH10851.1 | egtC | SAMN05421869_101487 | SAMN05421869_101485 | Pyridoxal 5-phosphate dependent beta-lyase. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.900 |
SDH10851.1 | egtD | SAMN05421869_101487 | SAMN05421869_101486 | Pyridoxal 5-phosphate dependent beta-lyase. | L-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.469 |
SDH12472.1 | egtC | SAMN05421869_101532 | SAMN05421869_101485 | Selenocysteine lyase/Cysteine desulfurase. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.605 |
SDI14752.1 | egtC | SAMN05421869_104397 | SAMN05421869_101485 | Selenocysteine lyase/Cysteine desulfurase. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.605 |
SDI16604.1 | SDI16647.1 | SAMN05421869_104447 | SAMN05421869_104448 | Cysteine desulfurase / selenocysteine lyase. | 5-histidylcysteine sulfoxide synthase. | 0.592 |
SDI16604.1 | SDI87835.1 | SAMN05421869_104447 | SAMN05421869_107337 | Cysteine desulfurase / selenocysteine lyase. | Selenocysteine lyase/Cysteine desulfurase. | 0.730 |
SDI16604.1 | egtC | SAMN05421869_104447 | SAMN05421869_101485 | Cysteine desulfurase / selenocysteine lyase. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.605 |
SDI16647.1 | SDI16604.1 | SAMN05421869_104448 | SAMN05421869_104447 | 5-histidylcysteine sulfoxide synthase. | Cysteine desulfurase / selenocysteine lyase. | 0.592 |
SDI16647.1 | egtC | SAMN05421869_104448 | SAMN05421869_101485 | 5-histidylcysteine sulfoxide synthase. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.628 |
SDI16647.1 | egtD | SAMN05421869_104448 | SAMN05421869_101486 | 5-histidylcysteine sulfoxide synthase. | L-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.724 |
SDI38604.1 | egtA | SAMN05421869_105289 | SAMN05421869_101483 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | 0.574 |
SDI38604.1 | egtC | SAMN05421869_105289 | SAMN05421869_101485 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.745 |
SDI38604.1 | egtD | SAMN05421869_105289 | SAMN05421869_101486 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | L-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.896 |
SDI87835.1 | SDI16604.1 | SAMN05421869_107337 | SAMN05421869_104447 | Selenocysteine lyase/Cysteine desulfurase. | Cysteine desulfurase / selenocysteine lyase. | 0.730 |
SDI87835.1 | egtC | SAMN05421869_107337 | SAMN05421869_101485 | Selenocysteine lyase/Cysteine desulfurase. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.739 |
egtA | SDH10851.1 | SAMN05421869_101483 | SAMN05421869_101487 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | Pyridoxal 5-phosphate dependent beta-lyase. | 0.460 |
egtA | SDI38604.1 | SAMN05421869_101483 | SAMN05421869_105289 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | 0.574 |
egtA | egtB | SAMN05421869_101483 | SAMN05421869_101484 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | iron(II)-dependent oxidoreductase; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. | 0.994 |
egtA | egtC | SAMN05421869_101483 | SAMN05421869_101485 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.976 |