node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bioB | bioD | HAH_1520 | HAH_1523 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
bioB | birA | HAH_1520 | HAH_0765 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | 0.976 |
bioB | nadA | HAH_1520 | HAH_0638 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.641 |
bioB | nadC1 | HAH_1520 | HAH_0636 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.443 |
bioB | queE | HAH_1520 | HAH_2646 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.517 |
bioD | bioB | HAH_1523 | HAH_1520 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.999 |
bioD | birA | HAH_1523 | HAH_0765 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | 0.747 |
bioD | nadA | HAH_1523 | HAH_0638 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.546 |
bioD | nadB | HAH_1523 | HAH_0637 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | L-aspartate oxidase. | 0.520 |
bioD | nadC1 | HAH_1523 | HAH_0636 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.611 |
bioD | queE | HAH_1523 | HAH_2646 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.460 |
bioD | thiL | HAH_1523 | HAH_0441 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.414 |
birA | bioB | HAH_0765 | HAH_1520 | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.976 |
birA | bioD | HAH_0765 | HAH_1523 | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.747 |
birA | nadA | HAH_0765 | HAH_0638 | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.570 |
birA | nadB | HAH_0765 | HAH_0637 | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | L-aspartate oxidase. | 0.546 |
birA | nadC1 | HAH_0765 | HAH_0636 | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.586 |
birA | nadE1 | HAH_0765 | HAH_2917 | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.585 |
birA | nit1 | HAH_0765 | HAH_1454 | biotin-[acetyl-CoA-carboxylase] ligase; BirA family transcriptional regulator; biotin operon repressor. | Nitrilase. | 0.648 |
cysE2 | nadA | HAH_1693 | HAH_0638 | Serine acetyltransferase. | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.847 |