node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dnaJ1 | dnaK1 | HAH_0574 | HAH_0579 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone. | 0.999 |
dnaJ1 | dnaK2 | HAH_0574 | HAH_4198 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Belongs to the heat shock protein 70 family. | 0.997 |
dnaJ1 | grpE | HAH_0574 | HAH_0580 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Heat shock protein GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.996 |
dnaJ1 | lonB | HAH_0574 | HAH_2425 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | ATP-dependent protease Lon; Belongs to the peptidase S16 family. | 0.701 |
dnaJ1 | thrS | HAH_0574 | HAH_0686 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.526 |
dnaJ1 | thsA2 | HAH_0574 | HAH_2341 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Thermosome alpha subunit; Belongs to the TCP-1 chaperonin family. | 0.893 |
dnaK1 | dnaJ1 | HAH_0579 | HAH_0574 | Chaperone protein DnaK; Acts as a chaperone. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.999 |
dnaK1 | dnaK2 | HAH_0579 | HAH_4198 | Chaperone protein DnaK; Acts as a chaperone. | Chaperone protein DnaK; Belongs to the heat shock protein 70 family. | 0.909 |
dnaK1 | grpE | HAH_0579 | HAH_0580 | Chaperone protein DnaK; Acts as a chaperone. | Heat shock protein GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.995 |
dnaK1 | infB | HAH_0579 | HAH_0458 | Chaperone protein DnaK; Acts as a chaperone. | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. | 0.547 |
dnaK1 | lonB | HAH_0579 | HAH_2425 | Chaperone protein DnaK; Acts as a chaperone. | ATP-dependent protease Lon; Belongs to the peptidase S16 family. | 0.776 |
dnaK1 | tbp | HAH_0579 | HAH_1334 | Chaperone protein DnaK; Acts as a chaperone. | Transcription factor / TATA-box binding family protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. | 0.456 |
dnaK1 | thrS | HAH_0579 | HAH_0686 | Chaperone protein DnaK; Acts as a chaperone. | threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.792 |
dnaK1 | thsA2 | HAH_0579 | HAH_2341 | Chaperone protein DnaK; Acts as a chaperone. | Thermosome alpha subunit; Belongs to the TCP-1 chaperonin family. | 0.874 |
dnaK2 | dnaJ1 | HAH_4198 | HAH_0574 | Chaperone protein DnaK; Belongs to the heat shock protein 70 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.997 |
dnaK2 | dnaK1 | HAH_4198 | HAH_0579 | Chaperone protein DnaK; Belongs to the heat shock protein 70 family. | Chaperone protein DnaK; Acts as a chaperone. | 0.909 |
dnaK2 | grpE | HAH_4198 | HAH_0580 | Chaperone protein DnaK; Belongs to the heat shock protein 70 family. | Heat shock protein GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.986 |
dnaK2 | infB | HAH_4198 | HAH_0458 | Chaperone protein DnaK; Belongs to the heat shock protein 70 family. | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. | 0.557 |
dnaK2 | lonB | HAH_4198 | HAH_2425 | Chaperone protein DnaK; Belongs to the heat shock protein 70 family. | ATP-dependent protease Lon; Belongs to the peptidase S16 family. | 0.780 |
dnaK2 | tbp | HAH_4198 | HAH_1334 | Chaperone protein DnaK; Belongs to the heat shock protein 70 family. | Transcription factor / TATA-box binding family protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. | 0.444 |