Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
mru_0803Hypothetical protein. (401 aa)    
Predicted Functional Partners:
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
 
 0.931
mru_0677
Hypothetical protein.
  
 0.898
psmA
Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
   
 
 0.850
mru_1168
Serine/threonine protein kinase with TPR repeats.
   
 0.694
mru_1860
ATPase.
 
 0.684
rpl40e
Ribosomal protein L40e Rpl40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.652
mru_0804
Hypothetical protein.
       0.651
mru_0435
Cell division control protein Cdc48.
  
 0.625
mru_0805
Hypothetical protein.
 
     0.479
mru_0638
Hypothetical protein.
  
     0.447
Your Current Organism:
Methanobrevibacter ruminantium
NCBI taxonomy Id: 634498
Other names: M. ruminantium M1, Methanobrevibacter ruminantium M1, Methanobrevibacter ruminantium str. M1, Methanobrevibacter ruminantium strain M1
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