STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EbC_08680Putative aminotransferase; silverDB:661Eb01175. (386 aa)    
Predicted Functional Partners:
EbC_08670
Possible hydrolase; silverDB:661Eb01174.
 
  
 0.949
mtnD
Strongly similar to methionine salvage pathway enzyme E-2/E-2; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
 
  
 0.713
mtnB
Probable aldolase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily.
 
  
 0.705
mtnC
Uncharacterized protein; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
 
   
 0.685
EbC_38330
Putative modulator of drug activity; silverDB:661Eb05020.
   
    0.493
metL
Bifunctional aspartokinase/homoserine dehydrogenase 2; silverDB:661Eb00205; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.491
thrA
Bifunctional aspartokinase/homoserine dehydrogenase; silverDB:661Eb00898; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.491
EbC_40470
Glutamate synthase, large subunit; silverDB:661Eb05304.
     
 0.488
kefG
Glutathione-regulated potassium-efflux system ancillary protein; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.
   
    0.404
Your Current Organism:
Erwinia billingiae
NCBI taxonomy Id: 634500
Other names: E. billingiae Eb661, Erwinia billingiae Eb661, Erwinia billingiae str. Eb661, Erwinia billingiae strain Eb661
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