node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKH89210.1 | AKH89305.1 | AAW15_08695 | AAW15_09215 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.823 |
AKH89210.1 | cbiA | AAW15_08695 | AAW15_06830 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.972 |
AKH89210.1 | cbiC | AAW15_08695 | AAW15_06840 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-8X methylmutase; Catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.886 |
AKH89210.1 | cobD | AAW15_08695 | AAW15_06835 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.916 |
AKH89210.1 | cobQ | AAW15_08695 | AAW15_08690 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobalamin biosynthesis protein CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.979 |
AKH89210.1 | hisB | AAW15_08695 | AAW15_05555 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazoleglycerol-phosphate dehydratase; Catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.994 |
AKH89210.1 | hisD | AAW15_08695 | AAW15_05565 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.936 |
AKH89210.1 | hisI | AAW15_08695 | AAW15_05535 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family. | 0.990 |
AKH89210.1 | trpD | AAW15_08695 | AAW15_09220 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.823 |
AKH89210.1 | tyrA | AAW15_08695 | AAW15_03015 | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Chorismate mutase; Catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.886 |
AKH89305.1 | AKH89210.1 | AAW15_09215 | AAW15_08695 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.823 |
AKH89305.1 | hisB | AAW15_09215 | AAW15_05555 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazoleglycerol-phosphate dehydratase; Catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.835 |
AKH89305.1 | hisD | AAW15_09215 | AAW15_05565 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.697 |
AKH89305.1 | hisI | AAW15_09215 | AAW15_05535 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family. | 0.920 |
AKH89305.1 | trpD | AAW15_09215 | AAW15_09220 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
AKH89305.1 | tyrA | AAW15_09215 | AAW15_03015 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Chorismate mutase; Catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.879 |
cbiA | AKH89210.1 | AAW15_06830 | AAW15_08695 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.972 |
cbiA | cbiC | AAW15_06830 | AAW15_06840 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-8X methylmutase; Catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
cbiA | cobD | AAW15_06830 | AAW15_06835 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.981 |
cbiA | cobQ | AAW15_06830 | AAW15_08690 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.989 |