node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACC80136.1 | ACC82813.1 | Npun_F1429 | Npun_F4445 | Aromatic amino acid beta-eliminating lyase/threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | PFAM: aminotransferase, class V; KEGG: ava:Ava_5058 aminotransferase, class V. | 0.921 |
ACC80136.1 | gcvP | Npun_F1429 | Npun_R3754 | Aromatic amino acid beta-eliminating lyase/threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.952 |
ACC80136.1 | glyA | Npun_F1429 | Npun_F5156 | Aromatic amino acid beta-eliminating lyase/threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
ACC82031.1 | ACC82556.1 | Npun_F3641 | Npun_R4179 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: ana:alr4255 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | 0.843 |
ACC82031.1 | gcvH | Npun_F3641 | Npun_R3755 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: ana:alr4255 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.802 |
ACC82031.1 | gcvP | Npun_F3641 | Npun_R3754 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: ana:alr4255 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.875 |
ACC82031.1 | gcvT | Npun_F3641 | Npun_R3756 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: ana:alr4255 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.806 |
ACC82031.1 | purQ | Npun_F3641 | Npun_F6583 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: ana:alr4255 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.906 |
ACC82556.1 | ACC82031.1 | Npun_R4179 | Npun_F3641 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: ana:alr4255 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.843 |
ACC82556.1 | ACC82813.1 | Npun_R4179 | Npun_F4445 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | PFAM: aminotransferase, class V; KEGG: ava:Ava_5058 aminotransferase, class V. | 0.900 |
ACC82556.1 | gcvH | Npun_R4179 | Npun_R3755 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.988 |
ACC82556.1 | gcvP | Npun_R4179 | Npun_R3754 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.954 |
ACC82556.1 | gcvT | Npun_R4179 | Npun_R3756 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.975 |
ACC82556.1 | glyA | Npun_R4179 | Npun_F5156 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
ACC82556.1 | purQ | Npun_R4179 | Npun_F6583 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.802 |
ACC82813.1 | ACC80136.1 | Npun_F4445 | Npun_F1429 | PFAM: aminotransferase, class V; KEGG: ava:Ava_5058 aminotransferase, class V. | Aromatic amino acid beta-eliminating lyase/threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.921 |
ACC82813.1 | ACC82556.1 | Npun_F4445 | Npun_R4179 | PFAM: aminotransferase, class V; KEGG: ava:Ava_5058 aminotransferase, class V. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: ava:Ava_1927 dihydrolipoamide dehydrogenase. | 0.900 |
ACC82813.1 | gcvH | Npun_F4445 | Npun_R3755 | PFAM: aminotransferase, class V; KEGG: ava:Ava_5058 aminotransferase, class V. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.916 |
ACC82813.1 | gcvP | Npun_F4445 | Npun_R3754 | PFAM: aminotransferase, class V; KEGG: ava:Ava_5058 aminotransferase, class V. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.934 |
ACC82813.1 | gcvT | Npun_F4445 | Npun_R3756 | PFAM: aminotransferase, class V; KEGG: ava:Ava_5058 aminotransferase, class V. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.932 |