node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cysE | glyA | ROD_42091 | ROD_24931 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.825 |
cysE | ilvA | ROD_42091 | ROD_39761 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.800 |
cysE | sdaA | ROD_42091 | ROD_18521 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | L-serine deaminase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.902 |
cysE | sdaB | ROD_42091 | ROD_28371 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | L-serine dehydratase 2 (L-serine deaminase 2); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.902 |
cysE | serB | ROD_42091 | ROD_49111 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | Phosphoserine phosphatase. | 0.834 |
cysE | tdcB | ROD_42091 | ROD_47601 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | Catabolic threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.800 |
cysE | tdcG | ROD_42091 | ROD_47641 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.902 |
cysE | trpA | ROD_42091 | ROD_17431 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.805 |
cysE | trpB | ROD_42091 | ROD_17421 | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.805 |
dsdA | ilvA | ROD_40531 | ROD_39761 | D-serine dehydratase. | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.906 |
dsdA | sdaA | ROD_40531 | ROD_18521 | D-serine dehydratase. | L-serine deaminase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.914 |
dsdA | sdaB | ROD_40531 | ROD_28371 | D-serine dehydratase. | L-serine dehydratase 2 (L-serine deaminase 2); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.914 |
dsdA | tdcB | ROD_40531 | ROD_47601 | D-serine dehydratase. | Catabolic threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.906 |
dsdA | tdcG | ROD_40531 | ROD_47641 | D-serine dehydratase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.914 |
glyA | cysE | ROD_24931 | ROD_42091 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine acetyltransferase; Belongs to the transferase hexapeptide repeat family. | 0.825 |
glyA | ilvA | ROD_24931 | ROD_39761 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.915 |
glyA | sdaA | ROD_24931 | ROD_18521 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine deaminase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.947 |
glyA | sdaB | ROD_24931 | ROD_28371 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase 2 (L-serine deaminase 2); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.947 |
glyA | serB | ROD_24931 | ROD_49111 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase. | 0.935 |
glyA | tdcB | ROD_24931 | ROD_47601 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Catabolic threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.938 |