STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypfHydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (747 aa)    
Predicted Functional Partners:
hypE
Hydrogenase isoenzymes formation protein.
 
 
 0.973
hypD
Hydrogenase isoenzymes formation protein; Belongs to the HypD family.
 
  
 0.893
hypC
Hydrogenase isoenzymes formation protein.
 
 
 0.869
hybG
Putative glutathione S-transferase (pseudogene); Pseudogene, fragmented by 100 aa deletion and frameshift mutation.
 
 
 0.868
hybC
Hydrogenase-2 large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 
 0.853
hypB
Hydrogenase isoenzymes nickel incorporation protein.
 
   
 0.840
hybD
Hydrogenase 2 maturation protease.
 
   
 0.839
hyb0
Hydrogenase-2 small chain.
 
 
 
 0.839
hybF
Probable hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.836
hypA
Accessory protein for nickel incorporation into hydrogenase 3; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.833
Your Current Organism:
Citrobacter rodentium
NCBI taxonomy Id: 637910
Other names: C. rodentium ICC168, Citrobacter rodentium ICC168, Citrobacter rodentium str. ICC168, Citrobacter rodentium strain ICC168
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.