STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metRTrans-activator of metE and metH (LysR-family transcriptional regulator); Belongs to the LysR transcriptional regulatory family. (317 aa)    
Predicted Functional Partners:
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
   
  
 0.931
metB
Cystathionine gamma-synthase.
   
  
 0.877
metE
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
  
 0.839
metA
Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
   
    0.746
metL
Bifunctional aspartokinase/homoserine dehydrogenase II]; In the C-terminal section; belongs to the homoserine dehydrogenase family.
   
  
 0.646
metJ
Repressor of the methionine regulon; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
   
  
 0.642
ROD_12021
LysR-family transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.616
ROD_49141
Putative LysR-family transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
  
     0.589
hdfR
LysR-family transcriptional regulator (H-NS-dependent flhD regulator); Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
  
     0.536
metI
D-methionine ABC transporter, permease protein.
   
    0.529
Your Current Organism:
Citrobacter rodentium
NCBI taxonomy Id: 637910
Other names: C. rodentium ICC168, Citrobacter rodentium ICC168, Citrobacter rodentium str. ICC168, Citrobacter rodentium strain ICC168
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.