STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhBTransketolase, pyridine binding domain protein; COG: COG0022; Pfam: PF02779,PF02780; InterPro: IPR005475. (325 aa)    
Predicted Functional Partners:
pdhA
Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 0.999
aceF
Putative dihydrolipoyllysine-residue acetyltransferase; COG: COG0508; Pfam: PF00364,PF02817,PF00198; InterPro: IPR001078.
 
 0.999
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.999
lpdA
Dihydrolipoyl dehydrogenase; COG: COG1249; Pfam: PF07992,PF00070,PF02852; InterPro: IPR006258.
 
 0.997
EEW38227.1
Pyridine nucleotide-disulfide oxidoreductase; COG: COG1249; Pfam: PF07992,PF00070,PF02852; InterPro: IPR013027.
  
 0.990
pyk
Pyruvate kinase; COG: COG0469; Pfam: PF00224,PF02887; InterPro: IPR001697; Belongs to the pyruvate kinase family.
  
 
 0.963
ldhA2
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.961
pflB
Formate C-acetyltransferase; COG: COG1882; Pfam: PF02901,PF01228; InterPro: IPR005949.
   
 
 0.955
tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 
 0.954
EEW38266.1
Hypothetical protein; 4.1.1.49.
   
 
 0.951
Your Current Organism:
Granulicatella adiacens
NCBI taxonomy Id: 638301
Other names: G. adiacens ATCC 49175, Granulicatella adiacens ATCC 49175, Granulicatella adiacens str. ATCC 49175, Granulicatella adiacens strain ATCC 49175
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