STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrCThreonine synthase; COG: COG0498; Pfam: PF00291; InterPro: IPR004450. (481 aa)    
Predicted Functional Partners:
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
 0.999
hom
Homoserine dehydrogenase; COG: COG0460; Pfam: PF03447,PF00742; InterPro: IPR001342.
 
 0.987
EEW37970.1
Aspartate kinase; COG: COG0527; Pfam: PF00696,PF01842; InterPro: IPR001341; Belongs to the aspartokinase family.
 
 
 0.876
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.725
ilvE
Branched-chain-amino-acid transaminase; COG: COG0115; Pfam: PF01063; InterPro: IPR001544.
  
 0.724
cysK
Cysteine synthase A; COG: COG0031; Pfam: PF00291; InterPro: IPR005859; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.710
mdsC
Phosphotransferase enzyme family; Pfam: PF01636.
    
 0.658
pheB
ACT domain protein; COG: COG4492; Pfam: PF01842; Belongs to the UPF0735 family.
 
  
 0.648
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
 
 0.597
relA2
RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.593
Your Current Organism:
Granulicatella adiacens
NCBI taxonomy Id: 638301
Other names: G. adiacens ATCC 49175, Granulicatella adiacens ATCC 49175, Granulicatella adiacens str. ATCC 49175, Granulicatella adiacens strain ATCC 49175
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