node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEW36605.1 | EEW37079.1 | HMPREF0444_1675 | HMPREF0444_1297 | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | 0.718 |
EEW36605.1 | dnaJ | HMPREF0444_1675 | HMPREF0444_0427 | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.803 |
EEW36605.1 | glnA | HMPREF0444_1675 | HMPREF0444_1593 | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | Glutamine synthetase, type I; COG: COG0174; Pfam: PF03951,PF00120; InterPro: IPR004809. | 0.738 |
EEW36605.1 | rpoA | HMPREF0444_1675 | HMPREF0444_1193 | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.756 |
EEW36605.1 | rpoB | HMPREF0444_1675 | HMPREF0444_0071 | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.729 |
EEW36605.1 | rpoC | HMPREF0444_1675 | HMPREF0444_0072 | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.711 |
EEW36605.1 | rpoD | HMPREF0444_1675 | HMPREF0444_0462 | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.747 |
EEW36605.1 | rpoZ | HMPREF0444_1675 | HMPREF0444_0710 | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.712 |
EEW37077.1 | EEW37078.1 | HMPREF0444_1295 | HMPREF0444_1296 | Hypothetical protein. | Hypothetical protein; COG: COG4377. | 0.705 |
EEW37077.1 | EEW37079.1 | HMPREF0444_1295 | HMPREF0444_1297 | Hypothetical protein. | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | 0.705 |
EEW37078.1 | EEW37077.1 | HMPREF0444_1296 | HMPREF0444_1295 | Hypothetical protein; COG: COG4377. | Hypothetical protein. | 0.705 |
EEW37078.1 | EEW37079.1 | HMPREF0444_1296 | HMPREF0444_1297 | Hypothetical protein; COG: COG4377. | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | 0.804 |
EEW37079.1 | EEW36605.1 | HMPREF0444_1297 | HMPREF0444_1675 | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | TipAS antibiotic-recognition domain protein; COG: COG0789; Pfam: PF00376,PF07739; InterPro: IPR012925. | 0.718 |
EEW37079.1 | EEW37077.1 | HMPREF0444_1297 | HMPREF0444_1295 | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | Hypothetical protein. | 0.705 |
EEW37079.1 | EEW37078.1 | HMPREF0444_1297 | HMPREF0444_1296 | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | Hypothetical protein; COG: COG4377. | 0.804 |
EEW37079.1 | dnaJ | HMPREF0444_1297 | HMPREF0444_0427 | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.803 |
EEW37079.1 | glnA | HMPREF0444_1297 | HMPREF0444_1593 | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | Glutamine synthetase, type I; COG: COG0174; Pfam: PF03951,PF00120; InterPro: IPR004809. | 0.738 |
EEW37079.1 | rpoA | HMPREF0444_1297 | HMPREF0444_1193 | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.721 |
EEW37079.1 | rpoB | HMPREF0444_1297 | HMPREF0444_0071 | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.729 |
EEW37079.1 | rpoC | HMPREF0444_1297 | HMPREF0444_0072 | Transcriptional regulator, MerR family; COG: COG0789; Pfam: PF00376; InterPro: IPR000551. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.711 |