node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEQ49507.1 | cbiE | HMPREF0908_0089 | HMPREF0908_0101 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | 0.849 |
EEQ49507.1 | cbiG | HMPREF0908_0089 | HMPREF0908_0098 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | CbiG; COG: COG2073; Pfam: PF01890; InterPro: IPR002750. | 0.975 |
EEQ49507.1 | cbiT | HMPREF0908_0089 | HMPREF0908_0100 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COG: COG2242; Pfam: PF08242; InterPro: IPR014008. | 0.858 |
EEQ49507.1 | cobB | HMPREF0908_0089 | HMPREF0908_0094 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.877 |
EEQ49507.1 | cobD | HMPREF0908_0089 | HMPREF0908_0091 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.865 |
EEQ49507.1 | cobQ | HMPREF0908_0089 | HMPREF0908_0092 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.905 |
EEQ49507.1 | cobS | HMPREF0908_0089 | HMPREF0908_0090 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.883 |
EEQ49507.1 | cobU | HMPREF0908_0089 | HMPREF0908_0093 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | Putative adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; COG: COG2087; Pfam: PF02283; InterPro: IPR003203. | 0.850 |
EEQ49507.1 | crcB | HMPREF0908_0089 | HMPREF0908_0087 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | Protein CrcB; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | 0.701 |
EEQ49507.1 | gpmB | HMPREF0908_0089 | HMPREF0908_0088 | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | Putative alpha-ribazole phosphatase; COG: COG0406; Pfam: PF00300; InterPro: IPR013078; Belongs to the phosphoglycerate mutase family. | 0.763 |
cbiE | EEQ49507.1 | HMPREF0908_0101 | HMPREF0908_0089 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | GHMP kinase, N-terminal domain protein; Pfam: PF00288; InterPro: IPR006204. | 0.849 |
cbiE | cbiG | HMPREF0908_0101 | HMPREF0908_0098 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | CbiG; COG: COG2073; Pfam: PF01890; InterPro: IPR002750. | 0.988 |
cbiE | cbiT | HMPREF0908_0101 | HMPREF0908_0100 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COG: COG2242; Pfam: PF08242; InterPro: IPR014008. | 0.999 |
cbiE | cobB | HMPREF0908_0101 | HMPREF0908_0094 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.965 |
cbiE | cobD | HMPREF0908_0101 | HMPREF0908_0091 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.934 |
cbiE | cobQ | HMPREF0908_0101 | HMPREF0908_0092 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.914 |
cbiE | cobS | HMPREF0908_0101 | HMPREF0908_0090 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.874 |
cbiE | cobU | HMPREF0908_0101 | HMPREF0908_0093 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | Putative adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; COG: COG2087; Pfam: PF02283; InterPro: IPR003203. | 0.864 |
cbiE | crcB | HMPREF0908_0101 | HMPREF0908_0087 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | Protein CrcB; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | 0.742 |
cbiE | gpmB | HMPREF0908_0101 | HMPREF0908_0088 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; COG: COG2241; Pfam: PF00590; InterPro: IPR012818. | Putative alpha-ribazole phosphatase; COG: COG0406; Pfam: PF00300; InterPro: IPR013078; Belongs to the phosphoglycerate mutase family. | 0.744 |