node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEQ48191.1 | nrdD | HMPREF0908_1528 | HMPREF0908_0606 | Hypothetical protein. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477; InterPro: IPR012833. | 0.804 |
EEQ48191.1 | queE | HMPREF0908_1528 | HMPREF0908_0178 | Hypothetical protein. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.763 |
EEQ49598.1 | psd | HMPREF0908_0180 | HMPREF0908_0182 | Glycosyltransferase, group 2 family protein; Pfam: PF00535; InterPro: IPR001173. | Phosphatidylserine decarboxylase; COG: COG0688; Pfam: PF02666; InterPro: IPR004428. | 0.815 |
EEQ49598.1 | pssA | HMPREF0908_0180 | HMPREF0908_0181 | Glycosyltransferase, group 2 family protein; Pfam: PF00535; InterPro: IPR001173. | CDP-diacylglycerol-serine O-phosphatidyltransferase; COG: COG1183; Pfam: PF01066; InterPro: IPR004533; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.815 |
EEQ49598.1 | queD | HMPREF0908_0180 | HMPREF0908_0179 | Glycosyltransferase, group 2 family protein; Pfam: PF00535; InterPro: IPR001173. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.679 |
EEQ49598.1 | queE | HMPREF0908_0180 | HMPREF0908_0178 | Glycosyltransferase, group 2 family protein; Pfam: PF00535; InterPro: IPR001173. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.664 |
folE | queC | HMPREF0908_1121 | HMPREF0908_0161 | Putative GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | 0.430 |
folE | queD | HMPREF0908_1121 | HMPREF0908_0179 | Putative GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.990 |
folE | queE | HMPREF0908_1121 | HMPREF0908_0178 | Putative GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.663 |
folE | queF | HMPREF0908_1121 | HMPREF0908_1005 | Putative GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | preQ(1) synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.430 |
guaA | pssA | HMPREF0908_0057 | HMPREF0908_0181 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | CDP-diacylglycerol-serine O-phosphatidyltransferase; COG: COG1183; Pfam: PF01066; InterPro: IPR004533; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.588 |
guaA | queD | HMPREF0908_0057 | HMPREF0908_0179 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.615 |
guaA | queE | HMPREF0908_0057 | HMPREF0908_0178 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.618 |
guaA | queF | HMPREF0908_0057 | HMPREF0908_1005 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | preQ(1) synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.630 |
nrdD | EEQ48191.1 | HMPREF0908_0606 | HMPREF0908_1528 | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477; InterPro: IPR012833. | Hypothetical protein. | 0.804 |
nrdD | queE | HMPREF0908_0606 | HMPREF0908_0178 | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477; InterPro: IPR012833. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.852 |
psd | EEQ49598.1 | HMPREF0908_0182 | HMPREF0908_0180 | Phosphatidylserine decarboxylase; COG: COG0688; Pfam: PF02666; InterPro: IPR004428. | Glycosyltransferase, group 2 family protein; Pfam: PF00535; InterPro: IPR001173. | 0.815 |
psd | pssA | HMPREF0908_0182 | HMPREF0908_0181 | Phosphatidylserine decarboxylase; COG: COG0688; Pfam: PF02666; InterPro: IPR004428. | CDP-diacylglycerol-serine O-phosphatidyltransferase; COG: COG1183; Pfam: PF01066; InterPro: IPR004533; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.998 |
psd | queD | HMPREF0908_0182 | HMPREF0908_0179 | Phosphatidylserine decarboxylase; COG: COG0688; Pfam: PF02666; InterPro: IPR004428. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.660 |
psd | queE | HMPREF0908_0182 | HMPREF0908_0178 | Phosphatidylserine decarboxylase; COG: COG0688; Pfam: PF02666; InterPro: IPR004428. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.653 |