node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEQ47661.1 | EEQ48191.1 | HMPREF0908_1963 | HMPREF0908_1528 | dTMP kinase; COG: COG0125; Pfam: PF02223; InterPro: IPR000062. | Hypothetical protein. | 0.601 |
EEQ47661.1 | adk | HMPREF0908_1963 | HMPREF0908_2034 | dTMP kinase; COG: COG0125; Pfam: PF02223; InterPro: IPR000062. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.672 |
EEQ47661.1 | dut | HMPREF0908_1963 | HMPREF0908_1790 | dTMP kinase; COG: COG0125; Pfam: PF02223; InterPro: IPR000062. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.891 |
EEQ47661.1 | ndk | HMPREF0908_1963 | HMPREF0908_1415 | dTMP kinase; COG: COG0125; Pfam: PF02223; InterPro: IPR000062. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.970 |
EEQ47661.1 | nrdD | HMPREF0908_1963 | HMPREF0908_0606 | dTMP kinase; COG: COG0125; Pfam: PF02223; InterPro: IPR000062. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477; InterPro: IPR012833. | 0.646 |
EEQ48191.1 | EEQ47661.1 | HMPREF0908_1528 | HMPREF0908_1963 | Hypothetical protein. | dTMP kinase; COG: COG0125; Pfam: PF02223; InterPro: IPR000062. | 0.601 |
EEQ48191.1 | adk | HMPREF0908_1528 | HMPREF0908_2034 | Hypothetical protein. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.492 |
EEQ48191.1 | grpE | HMPREF0908_1528 | HMPREF0908_1797 | Hypothetical protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.519 |
EEQ48191.1 | ndk | HMPREF0908_1528 | HMPREF0908_1415 | Hypothetical protein. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.459 |
EEQ48191.1 | nrdD | HMPREF0908_1528 | HMPREF0908_0606 | Hypothetical protein. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477; InterPro: IPR012833. | 0.804 |
EEQ48191.1 | nrdG | HMPREF0908_1528 | HMPREF0908_1529 | Hypothetical protein. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.984 |
EEQ48191.1 | pyrG | HMPREF0908_1528 | HMPREF0908_1064 | Hypothetical protein. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.434 |
EEQ48191.1 | queE | HMPREF0908_1528 | HMPREF0908_0178 | Hypothetical protein. | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.763 |
adk | EEQ47661.1 | HMPREF0908_2034 | HMPREF0908_1963 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | dTMP kinase; COG: COG0125; Pfam: PF02223; InterPro: IPR000062. | 0.672 |
adk | EEQ48191.1 | HMPREF0908_2034 | HMPREF0908_1528 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Hypothetical protein. | 0.492 |
adk | grpE | HMPREF0908_2034 | HMPREF0908_1797 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.612 |
adk | ndk | HMPREF0908_2034 | HMPREF0908_1415 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.935 |
adk | nrdD | HMPREF0908_2034 | HMPREF0908_0606 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477; InterPro: IPR012833. | 0.578 |
adk | pyrG | HMPREF0908_2034 | HMPREF0908_1064 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.660 |
adk | ribB | HMPREF0908_2034 | HMPREF0908_1392 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.570 |