node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEQ47870.1 | dnaJ | HMPREF0908_1799 | HMPREF0908_1795 | Hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.470 |
EEQ47870.1 | dnaK | HMPREF0908_1799 | HMPREF0908_1796 | Hypothetical protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.470 |
EEQ47870.1 | grpE | HMPREF0908_1799 | HMPREF0908_1797 | Hypothetical protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.544 |
EEQ47870.1 | hrcA | HMPREF0908_1799 | HMPREF0908_1798 | Hypothetical protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.544 |
EEQ49569.1 | EEQ49648.1 | HMPREF0908_0151 | HMPREF0908_0020 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.972 |
EEQ49569.1 | clpP | HMPREF0908_0151 | HMPREF0908_0140 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.980 |
EEQ49569.1 | dnaJ | HMPREF0908_0151 | HMPREF0908_1795 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.876 |
EEQ49569.1 | dnaK | HMPREF0908_0151 | HMPREF0908_1796 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.986 |
EEQ49569.1 | groL | HMPREF0908_0151 | HMPREF0908_1298 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.736 |
EEQ49569.1 | grpE | HMPREF0908_0151 | HMPREF0908_1797 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.853 |
EEQ49569.1 | hrcA | HMPREF0908_0151 | HMPREF0908_1798 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.670 |
EEQ49648.1 | EEQ49569.1 | HMPREF0908_0020 | HMPREF0908_0151 | Hypothetical protein. | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | 0.972 |
EEQ49648.1 | clpB | HMPREF0908_0020 | HMPREF0908_0053 | Hypothetical protein. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.972 |
EEQ49648.1 | clpP | HMPREF0908_0020 | HMPREF0908_0140 | Hypothetical protein. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.742 |
EEQ49648.1 | dnaJ | HMPREF0908_0020 | HMPREF0908_1795 | Hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.998 |
EEQ49648.1 | groL | HMPREF0908_0020 | HMPREF0908_1298 | Hypothetical protein. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.940 |
EEQ49648.1 | grpE | HMPREF0908_0020 | HMPREF0908_1797 | Hypothetical protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.990 |
EEQ49648.1 | hrcA | HMPREF0908_0020 | HMPREF0908_1798 | Hypothetical protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.838 |
clpB | EEQ49648.1 | HMPREF0908_0053 | HMPREF0908_0020 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.972 |
clpB | clpP | HMPREF0908_0053 | HMPREF0908_0140 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.977 |