STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Thal_0525TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: ank:AnaeK_2769 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)    
Predicted Functional Partners:
folD
Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.951
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.938
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.932
metE
5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
 
 0.909
Thal_0890
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.908
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.821
Thal_0523
PFAM: ribonuclease BN; KEGG: mfa:Mfla_2316 cyclic nucleotide-binding domain-containing protein.
  
    0.796
Thal_0526
Hypothetical protein.
       0.785
Thal_0524
TIGRFAM: lysine 2,3-aminomutase YodO family protein; KEGG: ade:Adeh_2548 L-lysine 2,3-aminomutase; PFAM: Radical SAM domain protein.
       0.773
Thal_0866
PFAM: NIL domain; KEGG: dat:HRM2_45870 putative ferredoxin.
   
  
 0.715
Your Current Organism:
Thermocrinis albus
NCBI taxonomy Id: 638303
Other names: T. albus DSM 14484, Thermocrinis albus DSM 14484, Thermocrinis albus HI 11/12, Thermocrinis albus str. DSM 14484, Thermocrinis albus strain DSM 14484
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