node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDC10888.1 | SDC37892.1 | SAMN04488239_101221 | SAMN04488239_102136 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.815 |
SDC10888.1 | SDC88595.1 | SAMN04488239_101221 | SAMN04488239_10449 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.970 |
SDC10888.1 | SDE69004.1 | SAMN04488239_101221 | SAMN04488239_12819 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.720 |
SDC10888.1 | ilvC | SAMN04488239_101221 | SAMN04488239_11218 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.823 |
SDC10888.1 | ilvD | SAMN04488239_101221 | SAMN04488239_10352 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.941 |
SDC10888.1 | ilvD-2 | SAMN04488239_101221 | SAMN04488239_11112 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.893 |
SDC10888.1 | leuA | SAMN04488239_101221 | SAMN04488239_102365 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.883 |
SDC10888.1 | leuB | SAMN04488239_101221 | SAMN04488239_103311 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.830 |
SDC37892.1 | SDC10888.1 | SAMN04488239_102136 | SAMN04488239_101221 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.815 |
SDC37892.1 | SDC64681.1 | SAMN04488239_102136 | SAMN04488239_10376 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | L-threonine ammonia-lyase. | 0.933 |
SDC37892.1 | SDC88595.1 | SAMN04488239_102136 | SAMN04488239_10449 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.991 |
SDC37892.1 | SDE69004.1 | SAMN04488239_102136 | SAMN04488239_12819 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.752 |
SDC37892.1 | ilvA | SAMN04488239_102136 | SAMN04488239_10980 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.943 |
SDC37892.1 | ilvC | SAMN04488239_102136 | SAMN04488239_11218 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.969 |
SDC37892.1 | ilvD | SAMN04488239_102136 | SAMN04488239_10352 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.516 |
SDC37892.1 | ilvD-2 | SAMN04488239_102136 | SAMN04488239_11112 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.553 |
SDC37892.1 | leuA | SAMN04488239_102136 | SAMN04488239_102365 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.850 |
SDC37892.1 | leuB | SAMN04488239_102136 | SAMN04488239_103311 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.843 |
SDC64681.1 | SDC37892.1 | SAMN04488239_10376 | SAMN04488239_102136 | L-threonine ammonia-lyase. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.933 |
SDC64681.1 | SDC88595.1 | SAMN04488239_10376 | SAMN04488239_10449 | L-threonine ammonia-lyase. | Acetolactate synthase, small subunit. | 0.957 |