STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
glnE(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (999 aa)    
Predicted Functional Partners:
glnD
UTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
 
   
 0.844
Snov_2222
KEGG: azc:AZC_1601 glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp.
 
  
 0.730
Snov_1337
PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; KEGG: mno:Mnod_6052 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen.
      0.638
Snov_0736
KEGG: xau:Xaut_3518 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein.
     
 0.608
Snov_0735
Two component transcriptional regulator, winged helix family; KEGG: azc:AZC_1137 response regulator receiver; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver.
     
 0.600
Snov_2713
KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein.
     
 0.580
Snov_2221
PFAM: nitrogen regulatory protein P-II; KEGG: rpt:Rpal_3314 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 
 0.578
Snov_3416
PFAM: nitrogen regulatory protein P-II; KEGG: azc:AZC_4227 GlnK protein; Belongs to the P(II) protein family.
 
 
 
 0.570
Snov_3415
KEGG: azc:AZC_4226 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter.
     
 0.508
Snov_0728
TIGRFAM: cytochrome c-type biogenesis protein CcmI; KEGG: azc:AZC_1132 cytochrome c-type biogenesis protein.
 
     0.437
Your Current Organism:
Starkeya novella
NCBI taxonomy Id: 639283
Other names: S. novella DSM 506, Starkeya novella DSM 506, Starkeya novella IAM 12100, Starkeya novella str. DSM 506, Starkeya novella strain DSM 506
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