| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Srot_0016 | Srot_1081 | Srot_0016 | Srot_1081 | Cell wall hydrolase/autolysin; KEGG: msm:MSMEG_6935 N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; Peptidoglycan- binding domain 1 protein; SMART: cell wall hydrolase/autolysin. | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | 0.401 |
| Srot_0016 | murA | Srot_0016 | Srot_0702 | Cell wall hydrolase/autolysin; KEGG: msm:MSMEG_6935 N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; Peptidoglycan- binding domain 1 protein; SMART: cell wall hydrolase/autolysin. | UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.809 |
| Srot_1081 | Srot_0016 | Srot_1081 | Srot_0016 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | Cell wall hydrolase/autolysin; KEGG: msm:MSMEG_6935 N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; Peptidoglycan- binding domain 1 protein; SMART: cell wall hydrolase/autolysin. | 0.401 |
| Srot_1081 | mraY | Srot_1081 | Srot_2585 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | phospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.927 |
| Srot_1081 | murA | Srot_1081 | Srot_0702 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.793 |
| Srot_1081 | murB | Srot_1081 | Srot_1490 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.537 |
| Srot_1081 | murC | Srot_1081 | Srot_2581 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.903 |
| Srot_1081 | murD | Srot_1081 | Srot_2584 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.815 |
| Srot_1081 | murE | Srot_1081 | Srot_2587 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.893 |
| Srot_1081 | murF | Srot_1081 | Srot_2586 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.877 |
| Srot_1081 | murG | Srot_1081 | Srot_2582 | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.888 |
| glmU | murA | Srot_2687 | Srot_0702 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.966 |
| glmU | murB | Srot_2687 | Srot_1490 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.585 |
| glmU | murC | Srot_2687 | Srot_2581 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.959 |
| glmU | murD | Srot_2687 | Srot_2584 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.665 |
| glmU | murE | Srot_2687 | Srot_2587 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.937 |
| glmU | murF | Srot_2687 | Srot_2586 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.649 |
| glmU | murG | Srot_2687 | Srot_2582 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.624 |
| mraY | Srot_1081 | Srot_2585 | Srot_1081 | phospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | KEGG: rop:ROP_08220 peptidoglycan synthase FtsI; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. | 0.927 |
| mraY | murA | Srot_2585 | Srot_0702 | phospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.854 |