STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Srot_2848PFAM: Xanthine/uracil/vitamin C permease; KEGG: mab:MAB_3353c putative xanthine/uracil/vitamin C permease family protein. (472 aa)    
Predicted Functional Partners:
Srot_2847
KEGG: mav:MAV_1011 hypothetical protein.
       0.762
Srot_2852
KEGG: rha:RHA1_ro04968 hypothetical protein.
      0.720
Srot_2849
PFAM: Protein of unknown function DUF2530; KEGG: rha:RHA1_ro04971 hypothetical protein.
       0.565
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.531
Srot_2158
KEGG: nml:Namu_0261 xanthine permease; TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; Oxo-4- hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase.
 
  
 0.523
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
  
  
 0.460
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.446
purD
TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: rop:ROP_48670 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP- grasp (A) domain; Phosphoribosylglycinamide synthetase, N- domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family.
  
  
 0.437
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
    0.437
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
    0.435
Your Current Organism:
Segniliparus rotundus
NCBI taxonomy Id: 640132
Other names: S. rotundus DSM 44985, Segniliparus rotundus ATCC BAA-972, Segniliparus rotundus CIP 108378, Segniliparus rotundus DSM 44985, Segniliparus rotundus JCM 13578, Segniliparus rotundus str. DSM 44985, Segniliparus rotundus strain DSM 44985
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