STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mhpAMonooxygenase FAD-binding protein; Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI). (617 aa)    
Predicted Functional Partners:
mhpB-2
Extradiol ring-cleavage dioxygenase class III protein subunit B; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively; Belongs to the LigB/MhpB extradiol dioxygenase family.
 
 
 0.969
mhpB
Extradiol ring-cleavage dioxygenase class III protein subunit B; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively; Belongs to the LigB/MhpB extradiol dioxygenase family.
 
 
 0.866
ADG19695.1
3-carboxyethylcatechol 2,3-dioxygenase; KEGG: rha:RHA1_ro00518 3-(2,3-dihydroxyphenyl)propionate dioxygenase; PFAM: Extradiol ring-cleavage dioxygenase class III protein subunit B.
 
 
 0.859
ADG18687.1
2-oxopent-4-enoate hydratase; KEGG: bxe:Bxe_B2327 putative 2-hydroxypenta-2,4-dienoate hydratase(MhpD); PFAM: fumarylacetoacetate (FAA) hydrolase.
 
  
 0.805
ADG18686.1
Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
  
 0.721
ADG18690.1
Transcriptional regulator, IclR family; KEGG: bxe:Bxe_B2330 DNA-binding transcriptional activator MhpR; PFAM: regulatory protein IclR; Transcriptional regulator IclR; SMART: regulatory protein IclR.
 
   
 0.696
ADG18685.1
4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 
 0.677
ADG18155.1
PFAM: monooxygenase FAD-binding; KEGG: bja:bll8212 hypothetical protein.
  
   
 0.579
mhpC
Alpha/beta hydrolase fold protein; Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid.
 
  
 0.476
ADG18163.1
PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: reu:Reut_B4341 ferredoxin:oxidoreductase FAD/NAD(P)-binding:oxidoreductase FAD-binding region.
 
 
 0.471
Your Current Organism:
Paraburkholderia sp. CCGE1002
NCBI taxonomy Id: 640511
Other names: P. sp. CCGE1002
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