STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEB72213.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (434 aa)    
Predicted Functional Partners:
SEB67024.1
2-oxoisovalerate dehydrogenase E1 component.
 
 0.999
SEB72144.1
Pyruvate dehydrogenase E1 component alpha subunit.
 
 0.997
SEB72181.1
Pyruvate dehydrogenase E1 component beta subunit.
 
 0.997
SEC09327.1
Pyruvate dehydrogenase E1 component beta subunit.
 
 0.992
SEC09299.1
Pyruvate dehydrogenase E1 component alpha subunit.
 
 0.990
SEC19732.1
Dihydrolipoamide dehydrogenase.
 0.990
SEC02727.1
2-oxoglutarate dehydrogenase E1 component.
 
0.968
SEC13627.1
Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.959
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.958
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.950
Your Current Organism:
Microbacterium humi
NCBI taxonomy Id: 640635
Other names: CCM 7687, DSM 21799, M. humi, Microbacterium humi Young et al. 2010, Microbacterium sp. CC-012309, strain CC-012309, strain CC-12309
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.