node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argB | dmd | VNG_1148G | VNG_0593G | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | Diphosphomevalonate decarboxylase; Dmd. | 0.983 |
argB | idi | VNG_1148G | VNG_1818G | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | Isopentenyl pyrophosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.983 |
argB | idsA | VNG_1148G | VNG_1150G | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | Geranylgeranyl diphosphate synthase; IdsA; Belongs to the FPP/GGPP synthase family. | 0.962 |
argB | mrp | VNG_1148G | VNG_1131G | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | Mrp protein homolog; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. | 0.665 |
argB | mvaB | VNG_1148G | VNG_1615G | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | 3-hydroxy-3-methylglutaryl-coenzyme A synthase; MvaB. | 0.724 |
argB | mvk | VNG_1148G | VNG_1145G | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.995 |
argB | rnj | VNG_1148G | VNG_1149C | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. | 0.609 |
carS | mvaA | VNG_2119C | VNG_1875G | Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; MvaA; Belongs to the HMG-CoA reductase family. | 0.567 |
carS | mvaB | VNG_2119C | VNG_1615G | Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 3-hydroxy-3-methylglutaryl-coenzyme A synthase; MvaB. | 0.586 |
carS | mvk | VNG_2119C | VNG_1145G | Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.782 |
dmd | argB | VNG_0593G | VNG_1148G | Diphosphomevalonate decarboxylase; Dmd. | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | 0.983 |
dmd | idi | VNG_0593G | VNG_1818G | Diphosphomevalonate decarboxylase; Dmd. | Isopentenyl pyrophosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.974 |
dmd | idsA | VNG_0593G | VNG_1150G | Diphosphomevalonate decarboxylase; Dmd. | Geranylgeranyl diphosphate synthase; IdsA; Belongs to the FPP/GGPP synthase family. | 0.596 |
dmd | mvaA | VNG_0593G | VNG_1875G | Diphosphomevalonate decarboxylase; Dmd. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; MvaA; Belongs to the HMG-CoA reductase family. | 0.941 |
dmd | mvaB | VNG_0593G | VNG_1615G | Diphosphomevalonate decarboxylase; Dmd. | 3-hydroxy-3-methylglutaryl-coenzyme A synthase; MvaB. | 0.988 |
dmd | mvk | VNG_0593G | VNG_1145G | Diphosphomevalonate decarboxylase; Dmd. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.999 |
idi | argB | VNG_1818G | VNG_1148G | Isopentenyl pyrophosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Ornithine carbamoyltransferase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. | 0.983 |
idi | dmd | VNG_1818G | VNG_0593G | Isopentenyl pyrophosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Diphosphomevalonate decarboxylase; Dmd. | 0.974 |
idi | idsA | VNG_1818G | VNG_1150G | Isopentenyl pyrophosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Geranylgeranyl diphosphate synthase; IdsA; Belongs to the FPP/GGPP synthase family. | 0.950 |
idi | mvaA | VNG_1818G | VNG_1875G | Isopentenyl pyrophosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; MvaA; Belongs to the HMG-CoA reductase family. | 0.948 |