atpE protein (Halobacterium salinarum) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

atpE

H+-transporting ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (195 aa)

Predicted Functional Partners:

atpD

0.999

atpB

0.999

atpA

0.999

atpF

0.999

atpC

0.999

atpK

0.999

atpI

0.999

atpH

0.998

ipp

0.927

gbp3

0.880

Your Current Organism:

Halobacterium salinarum

NCBI taxonomy Id: 64091
Other names: H. salinarum NRC-1, Halobacterium halobium NRC-1, Halobacterium salinarum NRC-1, Halobacterium salinarum str. NRC-1, Halobacterium salinarum strain NRC-1, Halobacterium sp. (strain NRC-1 / ATCC 700922 / JCM 11081), Halobacterium sp. (strain NRC-1), Halobacterium sp. ATCC 700922, Halobacterium sp. JCM 11081, Halobacterium sp. NRC-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
atpA	atpB	VNG_2139G	VNG_2138G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	0.999
atpA	atpC	VNG_2139G	VNG_2141G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	H+-transporting ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
atpA	atpD	VNG_2139G	VNG_2135G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	H+-transporting ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
atpA	atpE	VNG_2139G	VNG_2142G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	H+-transporting ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
atpA	atpF	VNG_2139G	VNG_2140G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	H+-transporting ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
atpA	atpH	VNG_2139G	VNG_2146H	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	Hypothetical protein; Vng2146h.	0.998
atpA	atpI	VNG_2139G	VNG_2144G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	H+-transporting ATP synthase subunit I; Produces ATP from ADP in the presence of a proton gradient across the membrane; Belongs to the V-ATPase 116 kDa subunit family.	0.999
atpA	atpK	VNG_2139G	VNG_2143G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	H+-transporting ATP synthase subunit K; AtpK.	0.999
atpA	gbp3	VNG_2139G	VNG_2410G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	GTP-binding protein homolog; Gbp3.	0.788
atpA	ipp	VNG_2139G	VNG_0259G	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.	0.958
atpB	atpA	VNG_2138G	VNG_2139G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	H+-transporting ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.	0.999
atpB	atpC	VNG_2138G	VNG_2141G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	H+-transporting ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
atpB	atpD	VNG_2138G	VNG_2135G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	H+-transporting ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
atpB	atpE	VNG_2138G	VNG_2142G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	H+-transporting ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
atpB	atpF	VNG_2138G	VNG_2140G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	H+-transporting ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
atpB	atpH	VNG_2138G	VNG_2146H	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	Hypothetical protein; Vng2146h.	0.995
atpB	atpI	VNG_2138G	VNG_2144G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	H+-transporting ATP synthase subunit I; Produces ATP from ADP in the presence of a proton gradient across the membrane; Belongs to the V-ATPase 116 kDa subunit family.	0.999
atpB	atpK	VNG_2138G	VNG_2143G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	H+-transporting ATP synthase subunit K; AtpK.	0.999
atpB	gbp3	VNG_2138G	VNG_2410G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	GTP-binding protein homolog; Gbp3.	0.843
atpB	ipp	VNG_2138G	VNG_0259G	H+-transporting ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.	Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.	0.941

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.814

expected number of edges:

11

PPI enrichment p-value:

2.02e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

10 of 446

1.13

1.52

8.02e-09

GO:0006810

Transport

11 of 578

1.06

1.38

3.59e-09

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015423

ABC-type maltose transporter activity

5 of 8

2.58

4.33

4.72e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

10 of 1090

0.74

0.69

2.10e-05

GO:0005886

Plasma membrane

11 of 1625

0.61

0.55

2.10e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8964

Mixed, incl. ABC-type maltose transporter activity, and Bacterial extracellular solute-binding protein

11 of 32

2.32

8.96

3.00e-22

CL:8966

Mixed, incl. ABC-type maltose transporter activity, and Bacterial extracellular solute-binding protein

7 of 22

2.28

5.51

1.30e-12

CL:8968

Mixed, incl. ABC-type maltose transporter activity, and MalK, OB fold domain

6 of 15

2.38

5.04

4.99e-11

CL:8970

Mixed, incl. MalK, OB fold domain, and ABC-type maltose transporter activity

2 of 8

2.18

0.88

0.0228

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 318

1.32

2.34

5.42e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

11 of 63

2.02

6.73

5.02e-20

GOCC:0055052

ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

6 of 37

1.99

3.9

7.64e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

10 of 197

1.49

2.91

1.63e-12

KW-1003

Cell membrane

10 of 212

1.45

2.79

1.66e-12

KW-0762

Sugar transport

2 of 6

2.3

1.39

0.0025

KW-1133

Transmembrane helix

10 of 1143

0.72

0.67

1.62e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

10 of 58

2.02

6.0

5.23e-17

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035906

MetI-like superfamily

10 of 58

2.02

5.91

1.31e-16

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

10 of 58

2.02

5.91

1.31e-16

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