node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFD37219.1 | SFD55673.1 | SAMN05216238_10135 | SAMN05216238_102195 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.673 |
SFD37219.1 | SFD58476.1 | SAMN05216238_10135 | SAMN05216238_102296 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.550 |
SFD37219.1 | SFD67255.1 | SAMN05216238_10135 | SAMN05216238_10388 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | UDP-galactose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | 0.545 |
SFD37219.1 | SFD94560.1 | SAMN05216238_10135 | SAMN05216238_10667 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | Ca-activated chloride channel family protein. | 0.553 |
SFD37219.1 | SFD96977.1 | SAMN05216238_10135 | SAMN05216238_106213 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | Competence protein ComFC. | 0.745 |
SFD37219.1 | SFE08397.1 | SAMN05216238_10135 | SAMN05216238_10836 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | Chlorite dismutase. | 0.816 |
SFD37219.1 | SFE17382.1 | SAMN05216238_10135 | SAMN05216238_109111 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | Farnesyl-diphosphate farnesyltransferase. | 0.572 |
SFD37219.1 | hemA | SAMN05216238_10135 | SAMN05216238_102299 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.534 |
SFD37219.1 | hemE | SAMN05216238_10135 | SAMN05216238_10133 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.999 |
SFD37219.1 | hemH | SAMN05216238_10135 | SAMN05216238_10134 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.999 |
SFD55673.1 | SFD37219.1 | SAMN05216238_102195 | SAMN05216238_10135 | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.673 |
SFD55673.1 | hemE | SAMN05216238_102195 | SAMN05216238_10133 | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.675 |
SFD55673.1 | hemH | SAMN05216238_102195 | SAMN05216238_10134 | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.463 |
SFD58476.1 | SFD37219.1 | SAMN05216238_102296 | SAMN05216238_10135 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.550 |
SFD58476.1 | hemA | SAMN05216238_102296 | SAMN05216238_102299 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.948 |
SFD58476.1 | hemE | SAMN05216238_102296 | SAMN05216238_10133 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.938 |
SFD67255.1 | SFD37219.1 | SAMN05216238_10388 | SAMN05216238_10135 | UDP-galactose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.545 |
SFD94560.1 | SFD37219.1 | SAMN05216238_10667 | SAMN05216238_10135 | Ca-activated chloride channel family protein. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.553 |
SFD94560.1 | hemE | SAMN05216238_10667 | SAMN05216238_10133 | Ca-activated chloride channel family protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.442 |
SFD94560.1 | hemH | SAMN05216238_10667 | SAMN05216238_10134 | Ca-activated chloride channel family protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.617 |