node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFD73466.1 | SFD94824.1 | SAMN05216238_103344 | SAMN05216238_10682 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | 0.918 |
SFD73466.1 | SFE25610.1 | SAMN05216238_103344 | SAMN05216238_11168 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.673 |
SFD73466.1 | apt | SAMN05216238_103344 | SAMN05216238_102251 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.925 |
SFD73466.1 | gmk | SAMN05216238_103344 | SAMN05216238_104221 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.944 |
SFD73466.1 | guaA | SAMN05216238_103344 | SAMN05216238_11154 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.965 |
SFD73466.1 | guaB | SAMN05216238_103344 | SAMN05216238_103270 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.961 |
SFD73466.1 | guaC | SAMN05216238_103344 | SAMN05216238_101363 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.921 |
SFD73466.1 | purA | SAMN05216238_103344 | SAMN05216238_103230 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.944 |
SFD73466.1 | purH | SAMN05216238_103344 | SAMN05216238_11176 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | IMP cyclohydrolase. | 0.939 |
SFD73466.1 | xpt | SAMN05216238_103344 | SAMN05216238_101365 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.930 |
SFD94824.1 | SFD73466.1 | SAMN05216238_10682 | SAMN05216238_103344 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.918 |
SFD94824.1 | SFE25610.1 | SAMN05216238_10682 | SAMN05216238_11168 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.789 |
SFD94824.1 | apt | SAMN05216238_10682 | SAMN05216238_102251 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.909 |
SFD94824.1 | gmk | SAMN05216238_10682 | SAMN05216238_104221 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.906 |
SFD94824.1 | guaA | SAMN05216238_10682 | SAMN05216238_11154 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.917 |
SFD94824.1 | guaB | SAMN05216238_10682 | SAMN05216238_103270 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.926 |
SFD94824.1 | guaC | SAMN05216238_10682 | SAMN05216238_101363 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.907 |
SFD94824.1 | purA | SAMN05216238_10682 | SAMN05216238_103230 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.914 |
SFD94824.1 | purH | SAMN05216238_10682 | SAMN05216238_11176 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | IMP cyclohydrolase. | 0.914 |
SFD94824.1 | xpt | SAMN05216238_10682 | SAMN05216238_101365 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.909 |