node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFD41156.1 | SFD52497.1 | SAMN05216238_101220 | SAMN05216238_10271 | Glycine cleavage system H protein (lipoate-binding). | Dihydrolipoamide dehydrogenase. | 0.925 |
SFD41156.1 | SFD83541.1 | SAMN05216238_101220 | SAMN05216238_104311 | Glycine cleavage system H protein (lipoate-binding). | Dihydrolipoamide dehydrogenase. | 0.928 |
SFD41156.1 | gcvH | SAMN05216238_101220 | SAMN05216238_106102 | Glycine cleavage system H protein (lipoate-binding). | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.944 |
SFD41156.1 | gcvPA | SAMN05216238_101220 | SAMN05216238_102112 | Glycine cleavage system H protein (lipoate-binding). | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.985 |
SFD41156.1 | gcvPB | SAMN05216238_101220 | SAMN05216238_102111 | Glycine cleavage system H protein (lipoate-binding). | Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.985 |
SFD41156.1 | gcvT | SAMN05216238_101220 | SAMN05216238_102113 | Glycine cleavage system H protein (lipoate-binding). | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.997 |
SFD41156.1 | glyA | SAMN05216238_101220 | SAMN05216238_10876 | Glycine cleavage system H protein (lipoate-binding). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
SFD52497.1 | SFD41156.1 | SAMN05216238_10271 | SAMN05216238_101220 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein (lipoate-binding). | 0.925 |
SFD52497.1 | SFD83541.1 | SAMN05216238_10271 | SAMN05216238_104311 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.956 |
SFD52497.1 | gcvH | SAMN05216238_10271 | SAMN05216238_106102 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.958 |
SFD52497.1 | gcvPA | SAMN05216238_10271 | SAMN05216238_102112 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.970 |
SFD52497.1 | gcvPB | SAMN05216238_10271 | SAMN05216238_102111 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.970 |
SFD52497.1 | gcvT | SAMN05216238_10271 | SAMN05216238_102113 | Dihydrolipoamide dehydrogenase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.975 |
SFD52497.1 | glyA | SAMN05216238_10271 | SAMN05216238_10876 | Dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
SFD83541.1 | SFD41156.1 | SAMN05216238_104311 | SAMN05216238_101220 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein (lipoate-binding). | 0.928 |
SFD83541.1 | SFD52497.1 | SAMN05216238_104311 | SAMN05216238_10271 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.956 |
SFD83541.1 | gcvH | SAMN05216238_104311 | SAMN05216238_106102 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.954 |
SFD83541.1 | gcvPA | SAMN05216238_104311 | SAMN05216238_102112 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.964 |
SFD83541.1 | gcvPB | SAMN05216238_104311 | SAMN05216238_102111 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.965 |
SFD83541.1 | gcvT | SAMN05216238_104311 | SAMN05216238_102113 | Dihydrolipoamide dehydrogenase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.968 |