node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | guaA | SAMN05216238_102251 | SAMN05216238_11154 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.991 |
apt | guaB | SAMN05216238_102251 | SAMN05216238_103270 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.934 |
apt | guaC | SAMN05216238_102251 | SAMN05216238_101363 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.925 |
apt | pyrG | SAMN05216238_102251 | SAMN05216238_10860 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.464 |
apt | xpt | SAMN05216238_102251 | SAMN05216238_101365 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.915 |
argS | guaA | SAMN05216238_10846 | SAMN05216238_11154 | arginyl-tRNA synthetase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.999 |
argS | guaB | SAMN05216238_10846 | SAMN05216238_103270 | arginyl-tRNA synthetase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.416 |
argS | lysS | SAMN05216238_10846 | SAMN05216238_103354 | arginyl-tRNA synthetase. | lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.960 |
argS | pyrG | SAMN05216238_10846 | SAMN05216238_10860 | arginyl-tRNA synthetase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.853 |
argS | rplK | SAMN05216238_10846 | SAMN05216238_11566 | arginyl-tRNA synthetase. | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.562 |
argS | tuf | SAMN05216238_10846 | SAMN05216238_11553 | arginyl-tRNA synthetase. | Translation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.418 |
guaA | apt | SAMN05216238_11154 | SAMN05216238_102251 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.991 |
guaA | argS | SAMN05216238_11154 | SAMN05216238_10846 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | arginyl-tRNA synthetase. | 0.999 |
guaA | guaB | SAMN05216238_11154 | SAMN05216238_103270 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | guaC | SAMN05216238_11154 | SAMN05216238_101363 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.999 |
guaA | lysS | SAMN05216238_11154 | SAMN05216238_103354 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.992 |
guaA | map | SAMN05216238_11154 | SAMN05216238_10717 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.995 |
guaA | pyrG | SAMN05216238_11154 | SAMN05216238_10860 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.996 |
guaA | rplK | SAMN05216238_11154 | SAMN05216238_11566 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.999 |
guaA | tuf | SAMN05216238_11154 | SAMN05216238_11553 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Translation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.991 |