node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | SAMN05421507_101328 | SAMN05421507_1011322 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Phosphoribosylanthranilate isomerase. | 0.974 |
guaA | hisB | SAMN05421507_101328 | SAMN05421507_1011311 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol-phosphate dehydratase. | 0.608 |
guaA | hisD | SAMN05421507_101328 | SAMN05421507_1011309 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.459 |
guaA | hisF | SAMN05421507_101328 | SAMN05421507_1011325 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.711 |
guaA | hisH | SAMN05421507_101328 | SAMN05421507_1011321 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.767 |
hisA | guaA | SAMN05421507_1011322 | SAMN05421507_101328 | Phosphoribosylanthranilate isomerase. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.974 |
hisA | hisB | SAMN05421507_1011322 | SAMN05421507_1011311 | Phosphoribosylanthranilate isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | SAMN05421507_1011322 | SAMN05421507_1011310 | Phosphoribosylanthranilate isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.975 |
hisA | hisD | SAMN05421507_1011322 | SAMN05421507_1011309 | Phosphoribosylanthranilate isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisE | SAMN05421507_1011322 | SAMN05421507_105335 | Phosphoribosylanthranilate isomerase. | phosphoribosyl-ATP pyrophosphohydrolase. | 0.995 |
hisA | hisF | SAMN05421507_1011322 | SAMN05421507_1011325 | Phosphoribosylanthranilate isomerase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SAMN05421507_1011322 | SAMN05421507_105336 | Phosphoribosylanthranilate isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.998 |
hisA | hisH | SAMN05421507_1011322 | SAMN05421507_1011321 | Phosphoribosylanthranilate isomerase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SAMN05421507_1011322 | SAMN05421507_1011327 | Phosphoribosylanthranilate isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | trpC | SAMN05421507_1011322 | SAMN05421507_1011333 | Phosphoribosylanthranilate isomerase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.968 |
hisB | guaA | SAMN05421507_1011311 | SAMN05421507_101328 | Imidazoleglycerol-phosphate dehydratase. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.608 |
hisB | hisA | SAMN05421507_1011311 | SAMN05421507_1011322 | Imidazoleglycerol-phosphate dehydratase. | Phosphoribosylanthranilate isomerase. | 0.998 |
hisB | hisC | SAMN05421507_1011311 | SAMN05421507_1011310 | Imidazoleglycerol-phosphate dehydratase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | SAMN05421507_1011311 | SAMN05421507_1011309 | Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | SAMN05421507_1011311 | SAMN05421507_105335 | Imidazoleglycerol-phosphate dehydratase. | phosphoribosyl-ATP pyrophosphohydrolase. | 0.995 |