node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDN81790.1 | SDN81824.1 | SAMN05421507_101374 | SAMN05421507_101375 | Dihydrofolate reductase. | Regulatory protein, tetR family. | 0.726 |
SDN81790.1 | SDP10898.1 | SAMN05421507_101374 | SAMN05421507_105269 | Dihydrofolate reductase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.755 |
SDN81790.1 | SDP54260.1 | SAMN05421507_101374 | SAMN05421507_11057 | Dihydrofolate reductase. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.761 |
SDN81790.1 | SDP95399.1 | SAMN05421507_101374 | SAMN05421507_12537 | Dihydrofolate reductase. | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.720 |
SDN81790.1 | SDP95898.1 | SAMN05421507_101374 | SAMN05421507_12636 | Dihydrofolate reductase. | Aminomethyltransferase; Belongs to the GcvT family. | 0.697 |
SDN81790.1 | gcvH | SAMN05421507_101374 | SAMN05421507_101646 | Dihydrofolate reductase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.702 |
SDN81790.1 | gcvH-2 | SAMN05421507_101374 | SAMN05421507_113103 | Dihydrofolate reductase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.702 |
SDN81790.1 | gcvP | SAMN05421507_101374 | SAMN05421507_113110 | Dihydrofolate reductase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.781 |
SDN81790.1 | gcvT | SAMN05421507_101374 | SAMN05421507_1011394 | Dihydrofolate reductase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.697 |
SDN81790.1 | thyA | SAMN05421507_101374 | SAMN05421507_10598 | Dihydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.908 |
SDN81824.1 | SDN81790.1 | SAMN05421507_101375 | SAMN05421507_101374 | Regulatory protein, tetR family. | Dihydrofolate reductase. | 0.726 |
SDP10898.1 | SDN81790.1 | SAMN05421507_105269 | SAMN05421507_101374 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydrofolate reductase. | 0.755 |
SDP10898.1 | SDP54260.1 | SAMN05421507_105269 | SAMN05421507_11057 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.875 |
SDP10898.1 | thyA | SAMN05421507_105269 | SAMN05421507_10598 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.873 |
SDP54260.1 | SDN81790.1 | SAMN05421507_11057 | SAMN05421507_101374 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase. | 0.761 |
SDP54260.1 | SDP10898.1 | SAMN05421507_11057 | SAMN05421507_105269 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.875 |
SDP54260.1 | SDP95399.1 | SAMN05421507_11057 | SAMN05421507_12537 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.551 |
SDP54260.1 | SDP95898.1 | SAMN05421507_11057 | SAMN05421507_12636 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.484 |
SDP54260.1 | gcvP | SAMN05421507_11057 | SAMN05421507_113110 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.536 |
SDP54260.1 | gcvT | SAMN05421507_11057 | SAMN05421507_1011394 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.484 |