node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDN81321.1 | SDP85657.1 | SAMN05421507_101356 | SAMN05421507_11739 | Phosphoribosylglycinamide formyltransferase-1. | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.833 |
SDN81321.1 | folD | SAMN05421507_101356 | SAMN05421507_101377 | Phosphoribosylglycinamide formyltransferase-1. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.987 |
SDN81321.1 | fumC | SAMN05421507_101356 | SAMN05421507_109159 | Phosphoribosylglycinamide formyltransferase-1. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.829 |
SDN81321.1 | glyA | SAMN05421507_101356 | SAMN05421507_1011395 | Phosphoribosylglycinamide formyltransferase-1. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
SDN81321.1 | glyA-2 | SAMN05421507_101356 | SAMN05421507_120133 | Phosphoribosylglycinamide formyltransferase-1. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
SDN81321.1 | mdh | SAMN05421507_101356 | SAMN05421507_101381 | Phosphoribosylglycinamide formyltransferase-1. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.749 |
SDN81321.1 | purL | SAMN05421507_101356 | SAMN05421507_10884 | Phosphoribosylglycinamide formyltransferase-1. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.999 |
SDN81321.1 | purU | SAMN05421507_101356 | SAMN05421507_10167 | Phosphoribosylglycinamide formyltransferase-1. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.923 |
SDO01081.1 | SDP85657.1 | SAMN05421507_1011038 | SAMN05421507_11739 | Malate synthase; Belongs to the malate synthase family. | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.938 |
SDO01081.1 | fumC | SAMN05421507_1011038 | SAMN05421507_109159 | Malate synthase; Belongs to the malate synthase family. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.915 |
SDO01081.1 | mdh | SAMN05421507_1011038 | SAMN05421507_101381 | Malate synthase; Belongs to the malate synthase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.935 |
SDO01081.1 | pckG | SAMN05421507_1011038 | SAMN05421507_12063 | Malate synthase; Belongs to the malate synthase family. | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.910 |
SDO01081.1 | purU | SAMN05421507_1011038 | SAMN05421507_10167 | Malate synthase; Belongs to the malate synthase family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.889 |
SDP85657.1 | SDN81321.1 | SAMN05421507_11739 | SAMN05421507_101356 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Phosphoribosylglycinamide formyltransferase-1. | 0.833 |
SDP85657.1 | SDO01081.1 | SAMN05421507_11739 | SAMN05421507_1011038 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate synthase; Belongs to the malate synthase family. | 0.938 |
SDP85657.1 | fumC | SAMN05421507_11739 | SAMN05421507_109159 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.982 |
SDP85657.1 | glyA | SAMN05421507_11739 | SAMN05421507_1011395 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.444 |
SDP85657.1 | glyA-2 | SAMN05421507_11739 | SAMN05421507_120133 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.444 |
SDP85657.1 | mdh | SAMN05421507_11739 | SAMN05421507_101381 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.998 |
SDP85657.1 | pckG | SAMN05421507_11739 | SAMN05421507_12063 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. | 0.924 |