STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDP71592.1DNA topoisomerase IB. (307 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.963
SDP94780.1
DNA gyrase subunit B.
   
 
 0.963
SDP27753.1
DNA helicase-2 / ATP-dependent DNA helicase PcrA.
    
 
 0.962
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.885
SDO47553.1
ATP-dependent DNA helicase RecQ.
 
 
 
 0.842
SDO12083.1
ATP-dependent DNA helicase RecQ.
   
 
 0.822
SDP53659.1
ATP-dependent DNA helicase RecQ.
    
 
 0.820
prfB
Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
    
   0.669
SDP83484.1
Ribosome-associated protein.
    
   0.669
SDP65932.1
Bifunctional non-homologous end joining protein LigD.
 
 
 
 0.628
Your Current Organism:
Lentzea jiangxiensis
NCBI taxonomy Id: 641025
Other names: CGMCC 4.6609, L. jiangxiensis, Lentzea jiangxiensis Li et al. 2012, Lentzea sp. FXJ1.034, NBRC 106680, strain FXJ1.034
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.