node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFI23213.1 | EFI24064.1 | HMPREF9016_01601 | HMPREF9016_00240 | Hypothetical protein. | Putative curved DNA-binding protein. | 0.885 |
EFI23213.1 | clpB | HMPREF9016_01601 | HMPREF9016_00317 | Hypothetical protein. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.771 |
EFI23213.1 | clpP | HMPREF9016_01601 | HMPREF9016_01035 | Hypothetical protein. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.410 |
EFI23213.1 | dnaJ | HMPREF9016_01601 | HMPREF9016_02025 | Hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.885 |
EFI23213.1 | dnaK | HMPREF9016_01601 | HMPREF9016_01554 | Hypothetical protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.958 |
EFI23213.1 | hscA | HMPREF9016_01601 | HMPREF9016_01144 | Hypothetical protein. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.958 |
EFI23213.1 | msrB | HMPREF9016_01601 | HMPREF9016_02032 | Hypothetical protein. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.661 |
EFI24064.1 | EFI23213.1 | HMPREF9016_00240 | HMPREF9016_01601 | Putative curved DNA-binding protein. | Hypothetical protein. | 0.885 |
EFI24064.1 | clpB | HMPREF9016_00240 | HMPREF9016_00317 | Putative curved DNA-binding protein. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.878 |
EFI24064.1 | clpP | HMPREF9016_00240 | HMPREF9016_01035 | Putative curved DNA-binding protein. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.526 |
EFI24064.1 | dnaK | HMPREF9016_00240 | HMPREF9016_01554 | Putative curved DNA-binding protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.989 |
EFI24064.1 | grpE | HMPREF9016_00240 | HMPREF9016_01555 | Putative curved DNA-binding protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.936 |
EFI24064.1 | hscA | HMPREF9016_00240 | HMPREF9016_01144 | Putative curved DNA-binding protein. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.982 |
EFI24064.1 | msrB | HMPREF9016_00240 | HMPREF9016_02032 | Putative curved DNA-binding protein. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.950 |
EFI24573.1 | clpB | HMPREF9016_00752 | HMPREF9016_00317 | Type VI secretion protein, EvpB/VC_A0108 family. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.719 |
clpB | EFI23213.1 | HMPREF9016_00317 | HMPREF9016_01601 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.771 |
clpB | EFI24064.1 | HMPREF9016_00317 | HMPREF9016_00240 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Putative curved DNA-binding protein. | 0.878 |
clpB | EFI24573.1 | HMPREF9016_00317 | HMPREF9016_00752 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Type VI secretion protein, EvpB/VC_A0108 family. | 0.719 |
clpB | clpP | HMPREF9016_00317 | HMPREF9016_01035 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.931 |
clpB | clpS | HMPREF9016_00317 | HMPREF9016_00289 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.729 |