STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acnBAconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (861 aa)    
Predicted Functional Partners:
gltA
Citrate (Si)-synthase; Belongs to the citrate synthase family.
  
 
 0.985
EFI24466.1
Isocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family.
   
 
 0.974
prpB
Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
     
 0.945
prpF
Putative AcnD-accessory protein PrpF.
    
 0.934
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.881
acnD
2-methylisocitrate dehydratase, Fe/S-dependent.
    
 0.859
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.
  
  
 0.845
sucA
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component.
   
  
 0.789
prpC
2-methylcitrate synthase; Belongs to the citrate synthase family.
  
 
 0.723
EFI24682.1
Putative malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
   
 
 0.713
Your Current Organism:
Neisseria sp. F0314
NCBI taxonomy Id: 641149
Other names: N. sp. oral taxon 014 str. F0314, Neisseria sp. oral taxon 014 str. F0314, Neisseria sp. oral taxon 014 strain F0314
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