node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFI22949.1 | EFI23547.1 | HMPREF9016_01334 | HMPREF9016_01939 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | AMP-binding enzyme. | 0.924 |
EFI22949.1 | EFI23554.1 | HMPREF9016_01334 | HMPREF9016_01947 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 3-oxoacyl-(acyl carrier protein) synthase III. | 0.893 |
EFI22949.1 | accA | HMPREF9016_01334 | HMPREF9016_00460 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. | 0.997 |
EFI22949.1 | accC | HMPREF9016_01334 | HMPREF9016_01336 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.999 |
EFI22949.1 | accD | HMPREF9016_01334 | HMPREF9016_01008 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.999 |
EFI22949.1 | aceF | HMPREF9016_01334 | HMPREF9016_00123 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.934 |
EFI22949.1 | fabD | HMPREF9016_01334 | HMPREF9016_02009 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | [acyl-carrier-protein] S-malonyltransferase. | 0.977 |
EFI22949.1 | fabH | HMPREF9016_01334 | HMPREF9016_02007 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 3-oxoacyl-(acyl carrier protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.982 |
EFI22949.1 | gltA | HMPREF9016_01334 | HMPREF9016_00935 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Citrate (Si)-synthase; Belongs to the citrate synthase family. | 0.933 |
EFI22949.1 | sucD | HMPREF9016_01334 | HMPREF9016_00928 | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | succinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.803 |
EFI23547.1 | EFI22949.1 | HMPREF9016_01939 | HMPREF9016_01334 | AMP-binding enzyme. | Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.924 |
EFI23547.1 | EFI23554.1 | HMPREF9016_01939 | HMPREF9016_01947 | AMP-binding enzyme. | 3-oxoacyl-(acyl carrier protein) synthase III. | 0.776 |
EFI23547.1 | accA | HMPREF9016_01939 | HMPREF9016_00460 | AMP-binding enzyme. | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. | 0.912 |
EFI23547.1 | accC | HMPREF9016_01939 | HMPREF9016_01336 | AMP-binding enzyme. | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.842 |
EFI23547.1 | accD | HMPREF9016_01939 | HMPREF9016_01008 | AMP-binding enzyme. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.927 |
EFI23547.1 | aceF | HMPREF9016_01939 | HMPREF9016_00123 | AMP-binding enzyme. | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.554 |
EFI23547.1 | fabD | HMPREF9016_01939 | HMPREF9016_02009 | AMP-binding enzyme. | [acyl-carrier-protein] S-malonyltransferase. | 0.848 |
EFI23547.1 | fabH | HMPREF9016_01939 | HMPREF9016_02007 | AMP-binding enzyme. | 3-oxoacyl-(acyl carrier protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.776 |
EFI23547.1 | gltA | HMPREF9016_01939 | HMPREF9016_00935 | AMP-binding enzyme. | Citrate (Si)-synthase; Belongs to the citrate synthase family. | 0.826 |
EFI23547.1 | sucD | HMPREF9016_01939 | HMPREF9016_00928 | AMP-binding enzyme. | succinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.685 |