node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFI23208.1 | aroC | HMPREF9016_01596 | HMPREF9016_00819 | Chorismate binding enzyme. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.977 |
EFI23208.1 | folP | HMPREF9016_01596 | HMPREF9016_01104 | Chorismate binding enzyme. | Dihydropteroate synthase. | 0.977 |
EFI23208.1 | leuA | HMPREF9016_01596 | HMPREF9016_00064 | Chorismate binding enzyme. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.921 |
EFI23208.1 | pabA | HMPREF9016_01596 | HMPREF9016_00423 | Chorismate binding enzyme. | Para-aminobenzoate synthase glutamine amidotransferase component II. | 0.999 |
EFI23208.1 | pheA | HMPREF9016_01596 | HMPREF9016_00985 | Chorismate binding enzyme. | Chorismate mutase. | 0.989 |
EFI23208.1 | trpA | HMPREF9016_01596 | HMPREF9016_01009 | Chorismate binding enzyme. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.921 |
EFI23208.1 | trpC | HMPREF9016_01596 | HMPREF9016_01602 | Chorismate binding enzyme. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.990 |
EFI23208.1 | trpD | HMPREF9016_01596 | HMPREF9016_00381 | Chorismate binding enzyme. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.998 |
EFI23208.1 | trpE | HMPREF9016_01596 | HMPREF9016_00118 | Chorismate binding enzyme. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.953 |
EFI23208.1 | trpF | HMPREF9016_01596 | HMPREF9016_00307 | Chorismate binding enzyme. | N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.943 |
aroC | EFI23208.1 | HMPREF9016_00819 | HMPREF9016_01596 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate binding enzyme. | 0.977 |
aroC | pabA | HMPREF9016_00819 | HMPREF9016_00423 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Para-aminobenzoate synthase glutamine amidotransferase component II. | 0.967 |
aroC | pheA | HMPREF9016_00819 | HMPREF9016_00985 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase. | 0.985 |
aroC | trpA | HMPREF9016_00819 | HMPREF9016_01009 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.722 |
aroC | trpC | HMPREF9016_00819 | HMPREF9016_01602 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.644 |
aroC | trpD | HMPREF9016_00819 | HMPREF9016_00381 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.714 |
aroC | trpE | HMPREF9016_00819 | HMPREF9016_00118 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.970 |
aroC | trpF | HMPREF9016_00819 | HMPREF9016_00307 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.599 |
folP | EFI23208.1 | HMPREF9016_01104 | HMPREF9016_01596 | Dihydropteroate synthase. | Chorismate binding enzyme. | 0.977 |
folP | pabA | HMPREF9016_01104 | HMPREF9016_00423 | Dihydropteroate synthase. | Para-aminobenzoate synthase glutamine amidotransferase component II. | 0.546 |