STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
T1G0L7_HELRONudix hydrolase domain-containing protein. (228 aa)    
Predicted Functional Partners:
T1FMH1_HELRO
Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.
  
 
 0.997
T1EG91_HELRO
Uncharacterized protein; Belongs to the FPP/GGPP synthase family.
 
 
 0.990
T1EMF5_HELRO
Uncharacterized protein; Belongs to the FPP/GGPP synthase family.
  
 
 0.983
T1G4K9_HELRO
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
  
 
 0.968
T1G1H8_HELRO
4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
  
 
 0.947
T1EM49_HELRO
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
  
 0.930
T1FMP5_HELRO
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
  
  
 0.928
T1FX17_HELRO
Alkyl transferase; Belongs to the UPP synthase family.
  
 
 0.869
T1FZC9_HELRO
Uncharacterized protein.
 
  
 0.868
T1ED11_HELRO
3-hydroxy-3-methylglutaryl coenzyme A reductase.
 
  
 0.867
Your Current Organism:
Helobdella robusta
NCBI taxonomy Id: 6412
Other names: H. robusta
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.