STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
T1G9R2_HELRODNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (857 aa)    
Predicted Functional Partners:
T1EGK8_HELRO
Uncharacterized protein.
   
 0.998
T1FQZ1_HELRO
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.998
T1FTJ5_HELRO
Uncharacterized protein.
    
 0.988
T1FHD6_HELRO
Uncharacterized protein.
    
 0.986
T1ES65_HELRO
Uncharacterized protein.
    
 0.985
T1F304_HELRO
RPA_C domain-containing protein.
    
 0.965
T1EG29_HELRO
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
  
0.907
T1FR89_HELRO
ERCC4 domain-containing protein.
    
 0.873
T1FZL0_HELRO
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.873
T1G373_HELRO
Uncharacterized protein.
  
 0.856
Your Current Organism:
Helobdella robusta
NCBI taxonomy Id: 6412
Other names: H. robusta
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