| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSATEP00000011608 | ENSATEP00000011761 | ENSATEP00000011608 | ENSATEP00000011761 | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.904 |
| ENSATEP00000011608 | ENSATEP00000012779 | ENSATEP00000011608 | ENSATEP00000012779 | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.942 |
| ENSATEP00000011608 | LOC113156869 | ENSATEP00000011608 | ENSATEP00000001082 | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.844 |
| ENSATEP00000011608 | LOC113162806 | ENSATEP00000011608 | ENSATEP00000006294 | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.923 |
| ENSATEP00000011608 | LOC113172448 | ENSATEP00000011608 | ENSATEP00000003110 | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.896 |
| ENSATEP00000011608 | dhcr7 | ENSATEP00000011608 | ENSATEP00000011120 | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | 7-dehydrocholesterol reductase. | 0.427 |
| ENSATEP00000011608 | sts | ENSATEP00000011608 | ENSATEP00000018324 | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Steroid sulfatase (microsomal), isozyme S. | 0.875 |
| ENSATEP00000011761 | ENSATEP00000011608 | ENSATEP00000011761 | ENSATEP00000011608 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | 0.904 |
| ENSATEP00000011761 | ENSATEP00000012779 | ENSATEP00000011761 | ENSATEP00000012779 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.547 |
| ENSATEP00000011761 | LOC113156869 | ENSATEP00000011761 | ENSATEP00000001082 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.835 |
| ENSATEP00000011761 | LOC113162806 | ENSATEP00000011761 | ENSATEP00000006294 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.454 |
| ENSATEP00000011761 | LOC113172448 | ENSATEP00000011761 | ENSATEP00000003110 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.898 |
| ENSATEP00000011761 | dhcr7 | ENSATEP00000011761 | ENSATEP00000011120 | Uncharacterized protein; Belongs to the cytochrome P450 family. | 7-dehydrocholesterol reductase. | 0.420 |
| ENSATEP00000011761 | sts | ENSATEP00000011761 | ENSATEP00000018324 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Steroid sulfatase (microsomal), isozyme S. | 0.872 |
| ENSATEP00000012779 | ENSATEP00000011608 | ENSATEP00000012779 | ENSATEP00000011608 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | 0.942 |
| ENSATEP00000012779 | ENSATEP00000011761 | ENSATEP00000012779 | ENSATEP00000011761 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.547 |
| ENSATEP00000012779 | ENSATEP00000022106 | ENSATEP00000012779 | ENSATEP00000022106 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.877 |
| ENSATEP00000012779 | LOC113156624 | ENSATEP00000012779 | ENSATEP00000021345 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.882 |
| ENSATEP00000012779 | LOC113156869 | ENSATEP00000012779 | ENSATEP00000001082 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.841 |
| ENSATEP00000012779 | LOC113162806 | ENSATEP00000012779 | ENSATEP00000006294 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.948 |