Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sike1Suppressor of IKBKE 1. (214 aa)    
Predicted Functional Partners:
tbk1
TANK-binding kinase 1.
    
 0.914
ikbke
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
    
 0.914
rnf8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
    
 
 0.882
mob4
MOB family member 4, phocein.
    
 
 0.876
ENSATEP00000005246
Chromatin licensing and DNA replication factor 1.
    
   0.799
LOC113167550
Uncharacterized protein.
    
 
 0.797
ENSATEP00000005712
Sarcolemma associated protein a.
    
 
 0.757
strip1
Striatin interacting protein 1.
    
 
 0.757
LOC113166722
Sarcolemma associated protein b.
    
 
 0.757
ENSATEP00000014516
Striatin interacting protein 2.
    
 
 0.757
Your Current Organism:
Anabas testudineus
NCBI taxonomy Id: 64144
Other names: A. testudineus, Amphiprion testudineus, Anthias testudineus, Antias testudineus, climbing perch
Server load: low (28%) [HD]