node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSATEP00000007203 | ENSATEP00000012235 | ENSATEP00000007203 | ENSATEP00000012235 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.830 |
ENSATEP00000007203 | pcna | ENSATEP00000007203 | ENSATEP00000029027 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.522 |
ENSATEP00000007203 | ube2c | ENSATEP00000007203 | ENSATEP00000014017 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. | 0.464 |
ENSATEP00000012235 | ENSATEP00000007203 | ENSATEP00000012235 | ENSATEP00000007203 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.830 |
ENSATEP00000012235 | ENSATEP00000018784 | ENSATEP00000012235 | ENSATEP00000018784 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | 0.866 |
ENSATEP00000012235 | ENSATEP00000027756 | ENSATEP00000012235 | ENSATEP00000027756 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.833 |
ENSATEP00000012235 | LOC113153717 | ENSATEP00000012235 | ENSATEP00000021688 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.830 |
ENSATEP00000012235 | birc5 | ENSATEP00000012235 | ENSATEP00000019436 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Baculoviral IAP repeat containing 5a. | 0.843 |
ENSATEP00000012235 | cdc20 | ENSATEP00000012235 | ENSATEP00000016373 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Cell division cycle 20 homolog. | 0.854 |
ENSATEP00000012235 | dlgap5 | ENSATEP00000012235 | ENSATEP00000018796 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Discs, large (Drosophila) homolog-associated protein 5. | 0.837 |
ENSATEP00000012235 | pcna | ENSATEP00000012235 | ENSATEP00000029027 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.864 |
ENSATEP00000012235 | smc2 | ENSATEP00000012235 | ENSATEP00000031422 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Structural maintenance of chromosomes protein. | 0.930 |
ENSATEP00000012235 | ube2c | ENSATEP00000012235 | ENSATEP00000014017 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. | 0.886 |
ENSATEP00000018784 | ENSATEP00000012235 | ENSATEP00000018784 | ENSATEP00000012235 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.866 |
ENSATEP00000018784 | ENSATEP00000027756 | ENSATEP00000018784 | ENSATEP00000027756 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.909 |
ENSATEP00000018784 | birc5 | ENSATEP00000018784 | ENSATEP00000019436 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | Baculoviral IAP repeat containing 5a. | 0.851 |
ENSATEP00000018784 | cdc20 | ENSATEP00000018784 | ENSATEP00000016373 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | Cell division cycle 20 homolog. | 0.855 |
ENSATEP00000018784 | dlgap5 | ENSATEP00000018784 | ENSATEP00000018796 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | Discs, large (Drosophila) homolog-associated protein 5. | 0.821 |
ENSATEP00000018784 | smc2 | ENSATEP00000018784 | ENSATEP00000031422 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | Structural maintenance of chromosomes protein. | 0.999 |
ENSATEP00000018784 | ube2c | ENSATEP00000018784 | ENSATEP00000014017 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. | Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. | 0.783 |