node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPR70066.1 | EPR70589.1 | ADIWIN_3929 | ADIWIN_3450 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Serine hydroxymethyltransferase. | 0.753 |
EPR70066.1 | EPR72642.1 | ADIWIN_3929 | ADIWIN_2255 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dihydrofolate reductase. | 0.733 |
EPR70066.1 | EPR72643.1 | ADIWIN_3929 | ADIWIN_2256 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.733 |
EPR70066.1 | fmt | ADIWIN_3929 | ADIWIN_1524 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.828 |
EPR70066.1 | gcvT | ADIWIN_3929 | ADIWIN_3776 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.866 |
EPR70066.1 | purH | ADIWIN_3929 | ADIWIN_0831 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.828 |
EPR70066.1 | purN | ADIWIN_3929 | ADIWIN_2627 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.836 |
EPR70066.1 | purU | ADIWIN_3929 | ADIWIN_1050 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.820 |
EPR70066.1 | thyA | ADIWIN_3929 | ADIWIN_2252 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.524 |
EPR70589.1 | EPR70066.1 | ADIWIN_3450 | ADIWIN_3929 | Serine hydroxymethyltransferase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.753 |
EPR70589.1 | EPR72642.1 | ADIWIN_3450 | ADIWIN_2255 | Serine hydroxymethyltransferase. | Dihydrofolate reductase. | 0.645 |
EPR70589.1 | EPR72643.1 | ADIWIN_3450 | ADIWIN_2256 | Serine hydroxymethyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.645 |
EPR70589.1 | fmt | ADIWIN_3450 | ADIWIN_1524 | Serine hydroxymethyltransferase. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.786 |
EPR70589.1 | gcvT | ADIWIN_3450 | ADIWIN_3776 | Serine hydroxymethyltransferase. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.991 |
EPR70589.1 | purH | ADIWIN_3450 | ADIWIN_0831 | Serine hydroxymethyltransferase. | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.939 |
EPR70589.1 | purN | ADIWIN_3450 | ADIWIN_2627 | Serine hydroxymethyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.904 |
EPR70589.1 | purU | ADIWIN_3450 | ADIWIN_1050 | Serine hydroxymethyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.771 |
EPR70589.1 | thyA | ADIWIN_3450 | ADIWIN_2252 | Serine hydroxymethyltransferase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.811 |
EPR72642.1 | EPR70066.1 | ADIWIN_2255 | ADIWIN_3929 | Dihydrofolate reductase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.733 |
EPR72642.1 | EPR70589.1 | ADIWIN_2255 | ADIWIN_3450 | Dihydrofolate reductase. | Serine hydroxymethyltransferase. | 0.645 |